Results 61 to 70 of about 391,496 (277)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
AN EMPIRICAL COMPARISON OF NEO4J AND TIGERGRAPH DATABASES FOR NETWORK CENTRALITY
Science Journal of University of Zakho, 2023 Graph databases have recently gained a lot of attention in areas where the relationships between data and the data itself are equally important, like the semantic web, social networks, and biological networks.
Bahzad Chicho +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Informatics Solutions for Prosumers connected to Smart Grids [PDF]
Database Systems Journal, 2015 This paper gives a brief overview about electricity consumption optimization based on consumption profiles of electricity prosumers that are connected to smart grids.
Simona Vasilica OPREA
doaj
The Use of Graph Databases for Artificial Neural Networks
Journal of Advanced Research in Natural and Applied Sciences, 2021 Storing and using trained artificial neural network (ANN) models face technical difficulties. These models are usually stored as files and cannot be run directly. An artificial neural network can be structurally expressed as a graph.
Ahmet Cumhur Kınacı +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A Brief Study of Open Source Graph Databases
, 2013 With the proliferation of large irregular sparse relational datasets, new storage and analysis platforms have arisen to fill gaps in performance and capability left by conventional approaches built on traditional database technologies and query languages.
Bader, David +4 more
core +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
GOMS: Large-scale ontology management system using graph databases
ETRI Journal, 2022 Large-scale ontology management is one of the main issues when using ontology data practically. Although many approaches have been proposed in relational database management systems (RDBMSs) or object-oriented DBMSs (OODBMSs) to develop large-scale ...
Chun-Hee Lee, Dong-oh Kang
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source