Results 81 to 90 of about 1,499,664 (294)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Analysis and design of multifunctional agricultural landscapes : a graph theoretic approach [PDF]
, 2008 This thesis deals with the development of quantitative methodologies for the evaluation of landscape functions and their interactions in multifunctional agricultural landscapes.
Jellema, A.
core
Kojaph: Visual Definition and Exploration of Patterns in Graph Databases
, 2015 We present Kojaph, a new system for the visual definition and exploration of patterns in graph databases. It offers an expressive visual language integrated in a simple user interface, to define complex patterns as a combination of topological properties
Montecchiani, Fabrizio +5 more
core +1 more source
Query execution time estimation in graph databases based on graph neural networks
Journal of King Saud University: Computer and Information SciencesQuery execution time estimation is an essential task for databases, accurate estimation results can help administrators to manage and monitor systems. This study proposes an interaction-aware and dependency-aware query execution time estimation approach ...
Zhenzhen He +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FG-Index: Towards Verification-Free Query Processing on
, 2008 Graphs are prevalently used to model the relationships between objects in various domains. With the increasing usage of graph databases, it has become more and more demanding to efficiently process graph queries.
Graph Databases
core
Converting relational databases into object relational databases [PDF]
, 2010 This paper proposes an approach for migrating existing Relational DataBases (RDBs) into Object-Relational DataBases (ORDBs). The approach is superior to existing proposals as it can generate not only the target schema but also the data instances.
Ali, Akhtar +5 more
core +2 more sources
World Electric Vehicle JournalThis article introduces a novel hybrid database architecture that combines graph and time-series databases to enhance the storage and management of transportation data, particularly for electric vehicles (EVs).
Marko Šidlovský, Filip Ravas
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source