Results 81 to 90 of about 130,993 (295)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Striving for Semantic Convergence with Fuzzy Cognitive Maps and Graph Databases
, 2017 The exponentially rising amounts of urban data demand new conceptual and technical methods for their management and storage. The era of the Semantic Web requires a convergence toward commonly shared meanings.
Edy Portmann +7 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Using Graph Databases to Represent Knowledge Base in the Field of Cultural Heritage
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2016 This paper presents digital knowledge including context-based annotations of objects in the field of cultural heritage. Some major problems and solutions of digitalization of items, their processing, storing and organizing them in a repository are ...
Galina Bogdanova +2 more
doaj +1 more source
FG-Index: Towards Verification-Free Query Processing on
, 2008 Graphs are prevalently used to model the relationships between objects in various domains. With the increasing usage of graph databases, it has become more and more demanding to efficiently process graph queries.
Graph Databases
core
Kojaph: Visual Definition and Exploration of Patterns in Graph Databases
, 2015 We present Kojaph, a new system for the visual definition and exploration of patterns in graph databases. It offers an expressive visual language integrated in a simple user interface, to define complex patterns as a combination of topological properties
Montecchiani, Fabrizio +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Action planning for graph transition systems
, 2005 Graphs are suitable modeling formalisms for software and hardware systems involving aspects such as communication, object orientation, concurrency, mobility and distribution.
Lluch-Lafuente, Alberto +5 more
core
Graph databases a comparativeanalysis
, 2023 I dagens samhälle är energieffektivisering en viktig parameter när man pratar om hållbar-het. Många fastigheter saknar tekniska lösningar för att effektivt övervaka och hantera en-ergiförbrukning. För att möta detta behov strävar företag som iquest efter
Lindström, Kasper, Lindqvist, Jonathan
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source