Results 81 to 90 of about 1,586,831 (297)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Optimizing large-scale graph database ingestion through edge value ranking: a proposed framework

Frontiers in Big Data
This paper proposes a preprocessing framework for optimizing large-scale graph database ingestion through intelligent edge filtering based on value ranking. We combine adapted PageRank algorithms with business-specific metrics and edge type importance to
Phanindra Reddy Madduru, Bijo Thomas
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Query execution time estimation in graph databases based on graph neural networks

Journal of King Saud University: Computer and Information Sciences
Query execution time estimation is an essential task for databases, accurate estimation results can help administrators to manage and monitor systems. This study proposes an interaction-aware and dependency-aware query execution time estimation approach ...
Zhenzhen He, Jiong Yu, Tiquan Gu, Dexian Yang   +3 more
doaj   +1 more source

Graph Databases and Graph Neural Networks [PDF]

Purpose - Nowadays, social networks, online media sharing and e-commerce platforms generate a vast amount of data, which, among other information, capture the interactions among the users.
Tsolakidis, Stratos, Triperina, Evangelia, Tsolakidis, Anastasios, Skourlas, Christos, Karanikolas, Νikitas   +4 more
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

VictorWinberg/graph-relational-benchmark: Version v1.0.0

, 2019
Release v1.0.0 graph-relational-benchmark This project enables you to benchmark graph and relational databases to compare their ...
Victor Winberg (7121042), Victor Winberg, Jan Zubac, Jan Zubac (7121045)   +3 more
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

HYDROGRAPH: EXPLORING GEOGRAPHIC DATA IN GRAPH DATABASES

Revista Brasileira de Cartografia, 2018
Water becomes, every day, more scarce. Reliable information about volume and quality in each watershed is important to management and proper planning of their use. Data-intensive science is being increasingly needed in this context.
Jaudete Daltio, Claudia Bauzer Medeiros
doaj