Results 91 to 100 of about 130,993 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Graph Homomorphism Revisited for Graph Matching

, 2010
In a variety of emerging applications one needs to decide whether a graph G matches another Gp, i.e., whether G has a topological structure similar to that of Gp. The traditional notions of graph homomorphism and isomorphism often fall short of capturing
Li, Jianzhong, Ma, Shuai, Fan, Wenfei; id_orcid, Wu, Yinghui, Wang, Hongzhi   +4 more
core  

Query Languages for Graph Databases

, 2018
In the past few years many NoSQL databases have emerged, including graph databases. NoSQL databases have certain advantages and they can be used in certain domains as an alternative to relational databases.
Kornelije Rabuzin
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Query execution time estimation in graph databases based on graph neural networks

Journal of King Saud University: Computer and Information Sciences
Query execution time estimation is an essential task for databases, accurate estimation results can help administrators to manage and monitor systems. This study proposes an interaction-aware and dependency-aware query execution time estimation approach ...
Zhenzhen He, Jiong Yu, Tiquan Gu, Dexian Yang   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

HYDROGRAPH: EXPLORING GEOGRAPHIC DATA IN GRAPH DATABASES

Revista Brasileira de Cartografia, 2018
Water becomes, every day, more scarce. Reliable information about volume and quality in each watershed is important to management and proper planning of their use. Data-intensive science is being increasingly needed in this context.
Jaudete Daltio, Claudia Bauzer Medeiros
doaj  

Graph Pattern Matching: From Intractable to Polynomial Time

, 2010
Graph pattern matching is typically defined in terms of sub-graph isomorphism, which makes it an np-complete problem. Moreover, it requires bijective functions, which are often too restrictive to characterize patterns in emerging applications. We propose
Li, Jianzhong, Tang, Nan, Ma, Shuai, Fan, Wenfei; id_orcid, Wu, Yunpeng, Wu, Yinghui   +5 more
core  

Converting relational to graph databases

, 2013
"Graph Database Management Systems provide an effective and efficient solution to data storage in current scenarios where data are more and more connected, graph models are widely used, and systems need to scale to large data sets. In this framework, the
DE VIRGILIO, ROBERTO, MACCIONI, ANTONIO, TORLONE, Riccardo, Antonio Maccioni, Riccardo Torlone, Roberto De Virgilio   +5 more
core   +1 more source