Results 91 to 100 of about 391,496 (277)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Temporal Paths in Real-World Sensor Networks

ISPRS International Journal of Geo-Information
Sensor networks are used in an increasing number and variety of application areas, like traffic control or river monitoring. Sensors in these networks measure parameters of interest defined by domain experts and send these measurements to a central ...
Erik Bollen, Bart Kuijpers, Valeria Soliani, Alejandro Vaisman   +3 more
doaj   +1 more source

Reshaping Smart Businesses with Cloud Database Solutions [PDF]

Database Systems Journal, 2015
The aim of this article is to show the importance of Big Data and its growing influence on companies. We can also see how much are the companies willing to invest in big data and how much are they currently gaining from their big data.
Bogdan NEDELCU, Andreea Maria IONESCU, Ana Maria IONESCU, Alexandru George VASILE   +3 more
doaj  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

The importance of graph databases and graph learning for clinical applications. [PDF]

Database (Oxford), 2023
Walke D, Micheel D, Schallert K, Muth T, Broneske D, Saake G, Heyer R.   +6 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

HYDROGRAPH: EXPLORING GEOGRAPHIC DATA IN GRAPH DATABASES

Revista Brasileira de Cartografia, 2018
Water becomes, every day, more scarce. Reliable information about volume and quality in each watershed is important to management and proper planning of their use. Data-intensive science is being increasingly needed in this context.
Jaudete Daltio, Claudia Bauzer Medeiros
doaj  

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Augmenting Orbital Debris Identification with Neo4j-Enabled Graph-Based Retrieval-Augmented Generation for Multimodal Large Language Models

Sensors
This preliminary study covers the construction and application of a Graph-based Retrieval-Augmented Generation (GraphRAG) system integrating a multimodal LLM, Large Language and Vision Assistant (LLaVA) with graph database software (Neo4j) to enhance LLM
Daniel S. Roll, Zeyneb Kurt, Yulei Li, Wai Lok Woo   +3 more
doaj   +1 more source