Results 111 to 120 of about 130,993 (295)

Analysis and design of multifunctional agricultural landscapes : a graph theoretic approach

, 2008
This thesis deals with the development of quantitative methodologies for the evaluation of landscape functions and their interactions in multifunctional agricultural landscapes.
Jellema, A.
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A discrete Reeb graph approach for the segmentation of human body scans [PDF]

, 2003
Segmentation of 3D human body (HB) scan is a very challenging problem in applications exploiting human scan data. To tackle this problem, we propose a topological approach based on discrete Reeb graph (DRG) which is an extension of the classical Reeb ...
Siebert, J.P., Werghi, N., Xiao, Y
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Augmenting Orbital Debris Identification with Neo4j-Enabled Graph-Based Retrieval-Augmented Generation for Multimodal Large Language Models

Sensors
This preliminary study covers the construction and application of a Graph-based Retrieval-Augmented Generation (GraphRAG) system integrating a multimodal LLM, Large Language and Vision Assistant (LLaVA) with graph database software (Neo4j) to enhance LLM
Daniel S. Roll, Zeyneb Kurt, Yulei Li, Wai Lok Woo   +3 more
doaj   +1 more source

An overview of graph databases and their applications in the biomedical domain. [PDF]

Database (Oxford), 2021
Timón-Reina S, Rincón M, Martínez-Tomás R.   +2 more
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Advantages of using graph databases to explore chromatin conformation capture experiments. [PDF]

BMC Bioinformatics, 2021
D'Agostino D, Liò P, Aldinucci M, Merelli I.   +3 more
europepmc   +1 more source

Graph kernel extensions and experiments with application to molecule classification, lead hopping and multiple targets

, 2009
The discovery of drugs that can effectively treat disease and alleviate pain is one of the core challenges facing modern medicine. The tools and techniques of machine learning have perhaps the greatest potential to provide a fast and efficient route ...
Demco, Anthony A, Demco, Anthony A.
core