Results 31 to 40 of about 51,611 (258)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Orthogonal Drawings of Plane Graphs Without Bends
Journal of Graph Algorithms and Applications, 2003 In an orthogonal drawing of a plane graph each vertex is drawn as a point and each edge is drawn as a sequence of vertical and horizontal line segments. A bend is a point at which the drawing of an edge changes its direction.
Md. Saidur Rahman +2 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Morphing Planar Graph Drawings with Bent Edges
Journal of Graph Algorithms and Applications, 2011 We give an algorithm to morph between two planar drawings of a graph, preserving planarity, but allowing edges to bend during the course of the morph. The morph is polynomial size and discrete: it uses a polynomial number of elementary steps, where each ...
Anna Lubiw, Mark Petrick
doaj +1 more source
The Complexity of Drawing a Graph in a Polygonal Region
Journal of Graph Algorithms and Applications, 2022 We prove that the following problem is complete for the existential theory of the reals: Given a planar graph and a polygonal region, with some vertices of the graph assigned to points on the boundary of the region, place the remaining vertices to ...
Anna Lubiw +2 more
doaj +1 more source
Pointed drawings of planar graphs [PDF]
Computational Geometry, 2012 We study the problem how to draw a planar graph crossing-free such that every vertex is incident to an angle greater than π. In general a plane straight-line drawing cannot guarantee this property. We present algorithms which construct such drawings with either tangent-continuous biarcs or quadratic Bézier curves (parabolic arcs), even if the positions
Oswin Aichholzer +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Journal of Graph Algorithms and Applications, 2020 We study the problem of drawing a dynamic graph, where each vertex appears in the graph at a certain time and remains in the graph for a fixed amount of time, called the window size.
Manuel Borrazzo +4 more
doaj +1 more source
Rectangular Drawings of Planar Graphs [PDF]
Journal of Algorithms, 2002 Summary: A plane graph is a planar graph with a fixed embedding in the plane. In a rectangular drawing of a plane graph, each vertex is drawn as a point, each edge is drawn as a horizontal or vertical line segment, and each face is drawn as a rectangle.
Md. Saidur Rahman 0001 +2 more
openaire +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source