Results 111 to 120 of about 649,217 (300)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

EGCPPIS: learning hierarchical equivariant graph representations with contrastive integration for protein–protein interaction site identification

BMC Bioinformatics
Background Protein–protein interactions regulate the dynamic operation of intracellular molecular networks, serving as the molecular basis for revealing protein functions and disease mechanisms.
Guicong Sun, Yongxian Fan, Yangfeng Zhu, Mengxin Zheng   +3 more
doaj   +1 more source

Talking Wikidata: Communication Patterns and Their Impact on Community Engagement in Collaborative Knowledge Graphs [PDF]

Transactions on Graph Data and Knowledge
We study collaboration patterns of Wikidata, one of the world's largest open source collaborative knowledge graph (KG) communities. Collaborative KG communities, play a key role in structuring machine-readable knowledge to support AI systems like ...
Koutsiana, Elisavet, Reklos, Ioannis, Alghamdi, Kholoud Saad, Jain, Nitisha, Meroño-Peñuela, Albert, Simperl, Elena   +5 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Graph Embeddings: Theory meets Practice (Dagstuhl Seminar 22132)

, 2022
Vectorial representations of graphs and relational structures, so-called graph embeddings, make it possible to apply standard tools from data mining, machine learning, and statistics to the graph domain.
Günnemann, Stephan, Jegelka, Stefanie, Grohe, Martin, Morris, Christopher   +3 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Embeddings of infinite graphs

Journal of Combinatorial Theory, Series B, 1988
Embeddings of infinite graphs in surfaces (not necessarily compact) without boundary are considered. Cellular embeddings are studied in details. Each rotation system of a locally finite graph G gives rise to a cellular embedding of G into some surface, and every cellular embedding with all 2-cells of finite size can be obtained in this way.
openaire   +2 more sources

Embedding Meshes on the Star Graph

Journal of Parallel and Distributed Computing, 1993
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Sanjay Ranka, Jhy-Chun Wang, Nangkang Yeh   +2 more
openaire   +3 more sources

Graph embeddings into Hamming spaces [PDF]

, 2022
Graph embeddings deal with injective maps from a given simple, undirected graph $G=(V,E)$ into a metric space, such as $\mathbb{R}^n$ with the Euclidean metric.
van der Zypen, Dominic
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source