Results 181 to 190 of about 2,840 (305)

Generalizing the Gaussian Network Model: Spanning‐Tree Thermodynamics Shows Entropy‐Driven KRAS Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The GTPase KRAS executes a conformational switch between a GTP‐bound active state and a GDP‐bound inactive state, a process central to oncogenic signaling. However, the structural basis of this switching at the level of residue‐contact organization remains incompletely characterized by traditional binary structural models.
Fatma Senguler Ciftci, Burak Erman
wiley   +1 more source

inMOTIFin: a lightweight end-to-end simulation software for regulatory sequences. [PDF]

Bioinformatics
Ferenc K, Martini L, Rauluseviciute I, Sandve GKF, Mathelier A.   +4 more
europepmc   +1 more source

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

scMetaTraj: A Metabolism‐Centered Framework for Trajectory Inference in Single‐Cell Data

Med Research, EarlyView.
Jinwei Dai, Zhihong Zuo, Xiaoyang Pang, Lixin Ke, Lina Zhang, Zhaoxin Qian   +5 more
wiley   +1 more source

Advancing SDG7–SDG13 Through Technology Innovation: The Environmental Impacts of Technological Advancements in Green, Fossil, and Energy Efficiency in Türkiye

Sustainable Development, EarlyView.
ABSTRACT Identifying the principal drivers of carbon emissions is vital for designing effective mitigation strategies and supporting long‐term environmental sustainability. Although previous studies have explored multiple determinants of emissions, limited attention has been paid to the most influential energy–technology channels within trade‐dependent
Gang Kou, Mustafa Naimoğlu, Serhat Yüksel, Hasan Dinçer   +3 more
wiley   +1 more source

Geranium: Multimodal Retrieval of Genomics Data Visualizations. [PDF]

IEEE Trans Vis Comput Graph
Nguyen HN, L'Yi S, Smits TC, Gao S, Zitnik M, Gehlenborg N.   +5 more
europepmc   +1 more source

Technological Innovation, Structural Transformation, and Policy Pathways to Energy Independence: Quantile Evidence From Türkiye in the Context of SDGs 7, 9, and 13

Sustainable Development, EarlyView.
ABSTRACT This study empirically examines the structural determinants of energy independence (EIND) in Türkiye over the period 1990–2023, with a particular focus on Total Factor Productivity (TFP), Energy Efficiency R&D Effectiveness (EERDE), and Renewable Energy R&D Effectiveness (RENRDE). Grounded in Endogenous Growth Theory and the Porter Hypothesis,
Mustafa Naimoglu, Oktay Özkan
wiley   +1 more source

Rules railroad: Syntax-inspired diagrams for visualizing and understanding rule-based model specifications. [PDF]

PLoS Comput Biol
Patel RJ, Blinov ML.
europepmc   +1 more source

Financial Inclusion for Smallholders: Integrating a Resource Nexus Approach Into Agricultural Finance Systems

Sustainable Development, EarlyView.
ABSTRACT Smallholder farmers remain structurally excluded from the current agricultural finance system. Existing research in this area examines financial inclusion through fragmented environmental, social, and economic lenses, limiting system‐level understanding.
Vaibhav Aggarwal, Matthias Walz, Edeltraud Guenther   +2 more
wiley   +1 more source

Synapsin Condensation is Governed by Sequence-Encoded Molecular Grammars. [PDF]

J Mol Biol
Hoffmann C, Ruff KM, Edu IA, Shinn MK, Tromm JV, King MR, Pant A, Ausserwöger H, Morgan JR, Knowles TPJ, Pappu RV, Milovanovic D.   +11 more
europepmc   +1 more source