Results 81 to 90 of about 2,840 (305)
Advanced Science, EarlyView.SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio +6 more
wiley +1 more source
Polarization Dynamics in Ferroelectrics: Insights Enabled by Machine Learning Molecular Dynamics
Advanced Science, EarlyView.Machine learning molecular dynamics is presented as a route to capture polarization switching, domain wall kinetics, topological polar textures, and polar mechanical coupling beyond the limits of conventional atomistic methods. This Perspective surveys recent progress and identifies key methodological directions, including long‐range electrostatics ...
Dongyu Bai +3 more
wiley +1 more source
A New Graph-Based Molecular Descriptor Using the Canonical Representation of the Molecule
The Scientific World Journal, 2014 Molecular similarity is a pervasive concept in drug design. The basic idea underlying molecular similarity is the similar property principle, which states that structurally similar molecules will exhibit similar physicochemical and biological properties.
Hamza Hentabli +3 more
doaj +1 more source
Action planning for graph transition systems [PDF]
, 2005 Graphs are suitable modeling formalisms for software and hardware systems involving aspects such as communication, object orientation, concurrency, mobility and distribution.
Lluch-Lafuente, Alberto +5 more
core
Advanced Science, EarlyView.As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang +11 more
wiley +1 more source
Empirical Risk Minimization with Approximations of Probabilistic Grammars [PDF]
, 2010 Probabilistic grammars are generative statistical models that are useful for compositional and sequential structures. We present a framework, reminiscent of structural risk minimization, for empirical risk minimization of the parameters of a fixed ...
Smith, N. A., Cohen, S. B.
core
Advanced Science, EarlyView.A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky +15 more
wiley +1 more source
Graph grammars with path-controlled embedding [PDF]
, 1991 In this paper we define graph grammars, called the node-replacement graph grammars with path-controlled embedding (nPCE grammars), which use a sequence of edges instead of a single edge to embed a newly replaced graph into the host graph.
Aizawa, Kunio, Nakamura, Akira
core +1 more source
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
Pair grammars, graph languages and string-to-graph translations [PDF]
, 1971 Translation between string and graph representations of programs and data may be formally defined by means of pair grammars. A pair grammar is composed of a pair of grammars whose rules and nonterminals are paired.
Terrence W. Pratt, Pratt, Terrence W.
core +1 more source