Results 61 to 70 of about 197,409 (310)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Isoperimetric Partitioning: A New Algorithm for Graph Partitioning [PDF]

, 2003
Temporal structure is skilled, fluent action exists at several nested levels. At the largest scale considered here, short sequences of actions that are planned collectively in prefronatal cortex appear to be queued for performance by a cyclic competitive
Grady, Leo, Schwartz, Eric
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

An Efficient CGM-Based Parallel Algorithm for Solving the Optimal Binary Search Tree Problem Through One-to-All Shortest Paths in a Dynamic Graph

Data Science and Engineering, 2019
The coarse-grained multicomputer parallel model (CGM for short) has been used for solving several classes of dynamic programming problems. In this paper, we propose a parallel algorithm on the CGM model, with p processors, for solving the optimal binary ...
Vianney Kengne Tchendji, Jerry Lacmou Zeutouo   +1 more
doaj   +1 more source

Recent Advances in Graph Partitioning

, 2015
We survey recent trends in practical algorithms for balanced graph partitioning together with applications and future research ...
A Buluç, A Felner, A George, A Lisser, A Pothen, A Trifunović, AB Kahng, AE Feldmann, AH Land, AJ Soper, B Brandfass, B Hendrickson, B Hendrickson, B Hendrickson, B Junker, B Monien, B Peng, BW Kernighan, C Aykanat, C Chevalier, C Chevalier, C Farhat, C Lanczos, C Walshaw, C Walshaw, C Walshaw, C Walshaw, C Walshaw, C Walshaw, CE Bichot, CE Ferreira, D Delling, D Delling, D Delling, D Drake, D Luxen, D Ron, D Ron, D Wagner, DA Papa, DE Drake Vinkemeier, E Jeannot, E Rolland, F Comellas, F Glover, F Glover, F Pellegrini, F Pellegrini, F Pellegrini, F Schulz, FT Leighton, G Even, G Karypis, G Karypis, G Karypis, G Zumbusch, H Li, H Meyerhenke, H Meyerhenke, H Meyerhenke, H Meyerhenke, H Meyerhenke, HD Simon, HD Simon, I Moulitsas, I Safro, I Safro, J Chen, J Cong, J Fietz, J Hromkovič, J Hungershöfer, J Maue, J Maue, J Shalf, JR Gilbert, K Andreev, K Lang, K Schloegel, K Schloegel, K Schloegel, KS Camilus, L Brunetta, L Grady, L Lovász, LA Sanchis, LR Ford, M Armbruster, M Bader, M Birn, M Fiedler, M Jerrum, M Newman, M Sellmann, M Zhou, MR Garey, N Sensen, O Goldschmidt, P Chardaire, P Galinier, P Korosec, P Sanders, P Sanders, R Diekmann, R Diekmann, R Glantz, R Preis, RD Williams, S Arora, S Huang, S Lafon, S Lloyd, S Pettie, SE Karisch, SY Chan, T Bui, T Kieritz, U Benlic, U Benlic, U Feige, V Osipov, WE Donath, WE Donath, WW Hager, WW Hager, X Sui, Y Low, YM Kim, Ü Çatalyürek   +128 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

\(k\)-efficient partitions of graphs

Communications in Combinatorics and Optimization, 2019
Summary: A set \(S = \{u_1,u_2, \dots, u_t\}\) of vertices of \(G\) is an efficient dominating set if every vertex of \(G\) is dominated exactly once by the vertices of \(S\). Letting \(U_i\) denote the set of vertices dominated by \(u_i\), we note that \(\{U_1, U_2, \dots, U_t\}\) is a partition of the vertex set of \(G\) and that each \(U_i ...
Chellali, Mustapha, Haynes, Teresa W., Hedetniemi, Stephen T.   +2 more
openaire   +4 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

PACC: Large scale connected component computation on Hadoop and Spark.

PLoS ONE, 2020
A connected component in a graph is a set of nodes linked to each other by paths. The problem of finding connected components has been applied to diverse graph analysis tasks such as graph partitioning, graph compression, and pattern recognition. Several
Ha-Myung Park, Namyong Park, Sung-Hyon Myaeng, U Kang   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source