Results 71 to 80 of about 768,033 (273)

Élaboration d'une nouvelle métaheuristique pour le partitionnement de graphe : la méthode de fusion-fission. Application au découpage de l'espace aérien [PDF]

, 2007
Dans cette thèse, nous étudions des méthodes de partitionnement de graphe et les appliquons au découpage de l'espace aérien, ainsi qu'à d'autres problèmes. L'espace aérien est composé de volumes limités, appelés secteurs de contrôle, chacun étant sous la
Bichot, Charles-Edmond
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Dynamic State-Space Partitioning in External-Memory Graph Search [PDF]

, 2010
State-of-the-art external-memory graph search algorithms rely on a hash function, or equivalently, a state-space projection function, that partitions the stored nodes of the state-space search graph into groups of nodes that are stored as separate ...
Eric A. Hansen, Rong Zhou, Zhou, Rong, Hansen, Eric, Hansen, Eric A.   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Convex Partitions of Graphs

Electronic Notes in Discrete Mathematics, 2007
Abstract A set of vertices S of a graph G is convex if all vertices of every geodesic between two of its vertices are in S . We say that G is k-convex if V ( G ) can be partitioned into k convex sets. The convex partition number of G is the least k ⩾ 2 for which G is k -convex.
Danilo Artigas, Mitre Costa Dourado, Jayme Luiz Szwarcfiter   +2 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

PACC: Large scale connected component computation on Hadoop and Spark.

PLoS ONE, 2020
A connected component in a graph is a set of nodes linked to each other by paths. The problem of finding connected components has been applied to diverse graph analysis tasks such as graph partitioning, graph compression, and pattern recognition. Several
Ha-Myung Park, Namyong Park, Sung-Hyon Myaeng, U Kang   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Polyhedral Computations for the Simple Graph Partitioning Problem [PDF]

The simple graph partitioning problem is to partition an edge-weighted graph into mutually disjoint subgraphs, each containing no more than b nodes, such that the sum of the weights of all edges in the subgraphs is maximal.
Sørensen, Michael M.
core