Results 61 to 70 of about 36,227 (305)
A survey of kernel and spectral methods for clustering [PDF]
, 2007 Clustering algorithms are a useful tool to explore data structures and have been employed in many disciplines. The focus of this paper is the partitioning clustering problem with a special interest in two recent approaches: kernel and spectral methods ...
Masulli, F. +11 more
core +1 more source
Generalized partitions of graphs
Discrete Applied Mathematics, 1999 The authors introduce a general graph partitioning problem: Let \(C\) be a class of graphs and \(H\) a fixed graph with vertex class \(V(H)=\{1,2,\dots,n\}\). An (resp. ONTO) \((H,C)\)-partition of a graph \(G\) is a partition \(V_1,V_2,\dots,V_n\) of \(V(G)\) such that, for each \(i\), the subgraph of \(G\) induced by \(V_i\) belongs to \(C\) and, if \
Gary MacGilivray, Min-Li Yu
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A Partition of Connected Graphs
The Electronic Journal of Combinatorics, 2005 We define an algorithm $k$ which takes a connected graph $G$ on a totally ordered vertex set and returns an increasing tree $R$ (which is not necessarily a subtree of $G$). We characterize the set of graphs $G$ such that $k(G)=R$. Because this set has a simple structure (it is isomorphic to a product of non-empty power sets), it is easy to evaluate ...
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Unfriendly partitions of a graph
Journal of Combinatorial Theory, Series B, 1990 An unfriendly partition of a graph (V,E) is a partition \(V=V_ 0\cup V_ 1\) such that for every vertex in \(V_ i\), the number of its neighbours in \(V_{1-i}\) is bigger or equal to that of its neighbours in \(V_ i\). The existence of an unfriendly partition of a graph (well-known if the graph is finite) is proved in the case (a) the graph has finitely
Ron Aharoni, E. C. Milner, Karel Prikry
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source