Results 121 to 130 of about 945,213 (292)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Domination Game Critical Graphs

Discussiones Mathematicae Graph Theory, 2015
The domination game is played on a graph G by two players who alternately take turns by choosing a vertex such that in each turn at least one previously undominated vertex is dominated. The game is over when each vertex becomes dominated.
Bujtás Csilla, Klavžar Sandi, Košmrlj Gašper   +2 more
doaj   +1 more source

The zero forcing number of graph powers

The $k$-th power of a simple graph $G$, denoted $G^k$, is the graph with vertex set $V(G)$ where two vertices are adjacent if they are within distance $k$ in $G$. We investigate the zero forcing number of graph powers.
Sjanne Zeijlemaker, Mary Flagg, Aida Abiad Monge, Sina Ghasemi Nezhad   +3 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A note on certain ergodicity coeflcients

Special Matrices, 2015
We investigate two ergodicity coefficients ɸ ∥∥ and τn−1, originally introduced to bound the subdominant eigenvalues of nonnegative matrices. The former has been generalized to complex matrices in recent years and several properties for such generalized ...
Tudisco Francesco
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Power spectrum signatures of graphs

Applied and Computational Harmonic Analysis
Point signatures based on the Laplacian operators on graphs, point clouds, and manifolds have become popular tools in machine learning for graphs, clustering, and shape analysis. In this work, we propose a novel point signature, the power spectrum signature, a measure on $\mathbb{R}$ defined as the squared graph Fourier transform of a graph signal ...
Ka Man Yim, Karamatou Yacoubou Djima
openaire   +2 more sources

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Computing Exact Edge Geodetic Numbers in K-Powered Path and Cycle Graphs

International Journal of Mathematics and Mathematical Sciences
For any two vertices u and v in a graph G, u−v geodesic is the shortest path between u and v. A set S of vertices in G is called an edge geodetic cover for G if every edge in G belongs to a geodesic between two vertices of S.
A. Baniabedalruhman, Basem Alkhamaiseh, M. M. M. Jaradat   +2 more
doaj   +1 more source