Results 111 to 120 of about 624,379 (287)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

A comparison of graph construction techniques for applying graph signal processing to soil moisture networks

open access: yesDiscover Computing
Sensor networks let a farmer keep their eye on multiple locations in an agricultural field simultaneously but can be expensive to install, maintain and analyse.
Jurgen van den Hoogen   +2 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing. [PDF]

open access: yesElife, 2021
Sandini C   +25 more
europepmc   +1 more source

Frames for Signal Processing on Cayley Graphs

open access: yesJournal of Fourier Analysis and Applications
The spectral decomposition of graph adjacency matrices is an essential ingredient in the design of graph signal processing (GSP) techniques. When the adjacency matrix has multi-dimensional eigenspaces, it is desirable to base GSP constructions on a particular eigenbasis that better reflects the graph's symmetries.
Kathryn Beck   +3 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Graph-Based EEG Signal Compression for Human–Machine Interaction

open access: yesIEEE Access
Communication of bioelectric signals, such as electroencephalography (EEG) signals, will be a key technology for smooth interaction between users and remote robots.
Takuya Fujihashi, Toshiaki Koike-Akino
doaj   +1 more source

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