Results 51 to 60 of about 144,663 (217)
Exact solutions for the time-evolution of quantum spin systems under arbitrary waveforms using algebraic graph theory [PDF]
, 2022 Pierre-Louis Giscard +1 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Construction of industry knowledge graph based on graph theory
大数据, 2023 China has the largest industrial scale and the most abundant industry type among the world.However, due to the influence of many factors, it is necessary to discover the blocking and breakpoints of the industrial chain, identify the stuck points, find ...
Zhenjun LI +6 more
doaj
KOALA GRAPH THEORY INTERNET SERVICE
TASK Quarterly, 2015 KOALA has been created with the idea of C++ library templates, implementing a broad set of procedures in the fields of algorithmic graph theory and network problems in discrete optimization.
TOMASZ GOLUCH +2 more
doaj +1 more source
Inventions, 2020 Graph theory (GT) concepts are potentially applicable in the field of computer science (CS) for many purposes. The unique applications of GT in the CS field such as clustering of web documents, cryptography, and analyzing an algorithm’s execution ...
Abdul Majeed, Ibtisam Rauf
doaj +1 more source
Rigidity percolation in a random tensegrity via analytic graph theory [PDF]
, 2023 W. Stephenson +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source