Results 81 to 90 of about 1,392,860 (268)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

Categorical constructions in graph theory

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1986
This paper presents some graph-theoretic questions from the viewpoint of the portion of category theory which has become common knowledge. In particular, the reader is encouraged to consider whether there is only one natural category of graphs and how ...
Richard T. Bumby, Dana May Latch
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Application of graph theory in liver research: A review

open access: yesPortal Hypertension & Cirrhosis
Graph theory has emerged as a valuable tool in liver research, aiding in the assessment of complex interactions underlying liver diseases at different organizational levels.
Xumei Hu   +7 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Computing Topological Indices for Para-Line Graphs of Anthracene

open access: yesOpen Chemistry, 2019
Atoms displayed as vertices and bonds can be shown by edges on a molecular graph. For such graphs we can find the indices showing their bioactivity as well as their physio-chemical properties such as the molar refraction, molar volume, chromatographic ...
Zhang Zhiqiang   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

行星轮系的图论模型及其应用

open access: yesJixie chuandong, 2008
Through analysis of the graph theory model,the conditions that the EGTs’ graph theory model must be met is summarized.On the basis of graph theory model presented in literature[1],a concept of module entity and basic loop in graph theory model is ...
史晓影, 陈良钰, 薛隆泉
doaj  

Limits of Ordered Graphs and their Applications

open access: yes, 2019
The emerging theory of graph limits exhibits an analytic perspective on graphs, showing that many important concepts and tools in graph theory and its applications can be described more naturally (and sometimes proved more easily) in analytic language ...
Ben-Eliezer, Omri   +3 more
core  

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri   +7 more
wiley   +1 more source

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