Results 41 to 50 of about 123,181 (264)

BRAIN CONNECTIONS ANALYSIS USING GRAPH THEORY MEASURES

open access: yesENVIRONMENT. TECHNOLOGIES. RESOURCES. Proceedings of the International Scientific and Practical Conference, 2019
Brain is a part of the organism’s complex structure that performs many functions, which are responsible for the main human abilities: to talk, to hear, to move, to see, etc. The brain consists of several areas that are not only directly connected with the different body systems, but also depend and may affect each other.
Minejeva, Oļesja   +2 more
openaire   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Regularity in Vague Intersection Graphs and Vague Line Graphs

open access: yesAbstract and Applied Analysis, 2014
Fuzzy graph theory is commonly used in computer science applications, particularly in database theory, data mining, neural networks, expert systems, cluster analysis, control theory, and image capturing.
Muhammad Akram   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Alterations of brain network topology and structural-functional connectivity coupling in noise-induced hearing loss based on macroscopic scale

open access: yesFrontiers in Neuroscience
ObjectiveTo investigate the changes in the global attributes of structural connectivity (SC) and functional connectivity (FC) graph theory, as well as the coupling topological structure of the whole brain SC-FC in patients with noise-induced hearing loss
Aijie Wang   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Graph analytic characterization of resting state networks in post-stroke aphasia

open access: yesFrontiers in Psychology, 2014
Introduction. There is recent evidence that suggests that resting-state abnormalities in chronic stroke likely influence recovery patterns. In this study, we examined resting state networks in 11 patients with post-stroke aphasia (PWA) in comparison to ...
Swathi Kiran
doaj   +1 more source

PAD: A graphical and numerical enhancement of structural coding to facilitate thematic analysis of a literature corpus

open access: yesMethodsX, 2022
We suggest an enhancement to structural coding through the use of (a) causally bound codes, (b) basic constructs of graph theory and (c) statistics. As is the norm with structural coding, the codes are collected into categories.
Etienne-Victor Depasquale   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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