Results 71 to 80 of about 12,540,238 (298)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

The structure of the models of decidable monadic theories of graphs

open access: yesAnnals of Pure and Applied Logic, 1991
The author devotes the bulk of this paper to a proof of the following undecidability result. If K is a class of graphs such that for each planar graph H there is a planar graph \(G\in K\) with H isomorphic to a minor of G, then both the second-order monadic and weak second-order monadic theories of K are undecidable. This generalizes an earlier theorem
openaire   +3 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Exploring the properties of benzenoid hydrocarbons through QSPR modeling and domination-based energy parameters

open access: yesScientific Reports
This article aims to explore two emerging areas of graph theory: chemical graph theory and domination theory. We specifically focus on a graph parameter that combines aspects of graph energy and domination, known as the dominating energy of a simple ...
Shanmugavelan Sankaran   +1 more
doaj   +1 more source

Theory and Calibration of Swap Market Models [PDF]

open access: yes
This paper introduces a general framework for market models, named Market Model Approach, through the concept of admissible sets of for-ward swap rates spanning a given tenor structure.
Z. Huang   +3 more
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

CHAPTERS

open access: yes, 2002
CHAPTERS 1. GRAPH THEORY CONCEPTS 1.1. GRAPHS 1.2. PROPERTIES OF GRAPHS 2.
Graph Theory Concepts, Alison Northup
core  

Expert interpretation of bar and line graphs: The role of graphicacy in reducing the effect of graph format. [PDF]

open access: yes, 2015
The distinction between informational and computational equivalence of representations, first articulated by Larkin and Simon (1987) has been a fundamental principle in the analysis of diagrammatic reasoning which has been supported empirically on ...
Ali, Nadia   +6 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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