Results 101 to 110 of about 1,282,535 (297)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Graph Visualization and Data Mining

, 2006
Graph Visualization, also known as Graph Drawing, is an emerging discipline that addresses the problem of conveying the structure of data space and of producing new knowledge of it by using diagrams.
DIDIMO, WALTER, Giuseppe Liotta, LIOTTA, Giuseppe, Walter Didimo   +3 more
core   +1 more source

Skeletal images as visual cues in graph visualization [PDF]

, 1998
The problem of graph layout and drawing is fundamental to many aproaches to the visualization of relational information structures. As the data set grows, the visualization problem is compounded by the need to reconcile the user's need for orientation ...
Melançon, G., I. Herman, J.-P. Domenger, M. Delest, Herman, I. (Ivan), Marshall, Scott, G. Melançon, Herman, Ivan, D. J. Duke, M. S. Marshall, Domenger, J.-P., Delest, M., Duke, D.J., Marshall, M.S. (Scott)   +13 more
core   +2 more sources

Medoid-based shadow value validation and visualization

IJAIN (International Journal of Advances in Intelligent Informatics), 2019
A silhouette index is a well-known measure of an internal criteria validation for the clustering algorithm results. While it is a medoid-based validation index, a centroid-based validation index that is called a centroid-based shadow value (CSV) has been
Weksi Budiaji
doaj   +1 more source

Graph Visualization: Alternative Models Inspired by Bioinformatics. [PDF]

Sensors (Basel), 2023
Kolomeets M, Desnitsky V, Kotenko I, Chechulin A.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Using adjacency matrices to lay out larger small-world networks [PDF]

, 2016
Many networks exhibit small-world properties. The structure of a small-world network is characterized by short average path lengths and high clustering coefficients.
Vickers, Paul, Gibson, Helen
core   +1 more source