Results 81 to 90 of about 267,239 (309)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Medoid-based shadow value validation and visualization

IJAIN (International Journal of Advances in Intelligent Informatics), 2019
A silhouette index is a well-known measure of an internal criteria validation for the clustering algorithm results. While it is a medoid-based validation index, a centroid-based validation index that is called a centroid-based shadow value (CSV) has been
Weksi Budiaji
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

ViAGraph : a Tool for Graph Visualization and Analysis [PDF]

, 2006
Graphs are common representations that can capture the structure and then can model a wide range of data and knowledge. In this paper, we present and discuss the functionalities of ViAGraph a tool for graph visualization and analysis.
Truong, Quoc Dinh, Dkaki, Taoufiq
core  

Gravisto: Graph Visualization Toolkit

, 2004
Gravisto, the Graph Visualization Toolkit, is more than a (Java-based) editor for graphs. It includes data structures, graph algorithms, several layout algorithms, and a graph viewer component.
Forster, Michael, Bachmaier, Christian, Michael Forster, Brandenburg, Franz J., Holleis, Paul, Raitner, Marcus, Franz J. Brandenburg, Marcus Raitner, Christian Bachmaier, Paul Holleis   +9 more
core   +1 more source

Enhancing Urban Data Analysis: Leveraging Graph-Based Convolutional Neural Networks for a Visual Semantic Decision Support System

Sensors
The persistent increase in the magnitude of urban data, combined with the broad range of sensors from which it derives in modern urban environments, poses issues including data integration, visualization, and optimal utilization. The successful selection
Nikolaos Sideris, Georgios Bardis, Athanasios Voulodimos, Georgios Miaoulis, Djamchid Ghazanfarpour   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Skeletal images as visual cues in graph visualization [PDF]

, 1998
The problem of graph layout and drawing is fundamental to many aproaches to the visualization of relational information structures. As the data set grows, the visualization problem is compounded by the need to reconcile the user's need for orientation ...
Melançon, G., I. Herman, J.-P. Domenger, M. Delest, Herman, I. (Ivan), Marshall, Scott, G. Melançon, Herman, Ivan, D. J. Duke, M. S. Marshall, Domenger, J.-P., Delest, M., Duke, D.J., Marshall, M.S. (Scott)   +13 more
core   +1 more source

Multilevel visualization of clustered graphs [PDF]

, 1997
Clustered graphs are graphs with recursive clustering structures over the vertices. This type of structure appears in many systems. Examples include CASE tools, management information systems, VLSI design tools, and reverse engineering systems. Existing layout algorithms represent the clustering structure as recursively nested regions in the plane ...
Peter Eades, Qing-Wen Feng
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source