Results 91 to 100 of about 858,549 (350)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

The analysis of ink jet printed eco-font efficiency

open access: yesJournal of Graphic Engineering and Design, 2016
Utilization of eco-font for office printing is one of sustainable, “green” printing concepts, which besides obvious economic benefits, as a result has a certain effect on environmental sustainability as well.
Rastko Milošević   +4 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Ensuring Southern Spain’s Energy Future: A LEAP-Based Scenario for Meeting 2030 and 2050 Goals

open access: yesApplied Sciences
The transition towards a low-carbon energy system remains a critical challenge for regions heavily dependent on fossil fuels, such as Andalusia. This study proposes an energy planning framework based on the Low Emissions Analysis Platform (LEAP) to model
Lucía Galán-Cano   +3 more
doaj   +1 more source

Army-NASA aircrew/aircraft integration program (A3I) software detailed design document, phase 3 [PDF]

open access: yes
The capabilities and design approach of the MIDAS (Man-machine Integration Design and Analysis System) computer-aided engineering (CAE) workstation under development by the Army-NASA Aircrew/Aircraft Integration Program is detailed. This workstation uses
Banda, Carolyn   +6 more
core   +1 more source

Spaces In, Outside Of, and Between [PDF]

open access: yes, 2019
My practice involves leveraging analog and digital techniques from many disciplines, but especially graphic design, craft/material studies, and sculpture.
Peterein, Michelle
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The Effects of Light Intensity on Tracing Digital Image into Vector Image

open access: yesJournal of Architecture, Art & Humanistic Science, 2018
This paper aims to study the effects of light intensity on the digital image production, and therefore the accurate reproduction of details when tracing this digital image to the vector image.
Tarek Hamd Allah
doaj   +1 more source

Purposive Pattern Recognition: The Nature of Visual Choice in Graphic Design [PDF]

open access: yes, 2009
Every pamphlet, brochure, booklet, advert, package, poster, etc that has ever been produced involved a visual choice made by a human being - even if the choice were restricted to ‘doing it like the last time’ or ‘copy this one’. Whether graphic designer,
Abu-Risha, Maria, Langrish, John Z
core  

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