Results 191 to 200 of about 47,436 (306)

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Graphic Novel for Patients Affected by Pancreatic Lesions Undergoing Endoscopic Ultrasound with Fine Needle Biopsy: A Pilot Randomized Study. [PDF]

Healthcare (Basel)
Rizzo GEM, Infantino G, Tuzzolino F, Traina M, Di Piazza G, La Milia D, Rancatore G, Carrozza L, Quintini D, Ligresti D, Pizzicannella M, Belluardo N, D'amore E, Rizzo G, Di Benedetto C, Palazzo U, Tarantino I.   +16 more
europepmc   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Perceptions of the Proposed Food and Drug Administration Graphic Cigarette Warnings Among Adults Who Smoke on a Nondaily or Daily Basis: A Within-Subjects Experiment. [PDF]

AJPM Focus
Fennell BS, Magnan RE, Vidrine JI, Vidrine DJ, Cameron LD.   +4 more
europepmc   +1 more source

Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces

Advanced Science, EarlyView.
System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee, Hyun Bin Kim, Sang Uk Park, Janghoon Joo, Jinhong Min, Geumbee Lee, Joohoon Kang, Hyoyoung Jeong, Jae‐Young Yoo, Sang Min Won   +9 more
wiley   +1 more source

Verbal and Visuo-Graphic Measures of Illness Perceptions Predict Quality of Life and Symptoms Among Patients With Interstitial Lung Disease. [PDF]

J Cardiopulm Rehabil Prev
Emery CF, Rodriguez I, Bhatt N, Esguerra V, Staaby A.   +4 more
europepmc   +1 more source

Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design

Advanced Science, EarlyView.
A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram, Mohit Chakraborty, Sai Mani Kumar Devathi, B. Pabitramohan Prusty, Rohit Batra   +4 more
wiley   +1 more source

Comment on "CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis". [PDF]

J Orthop Translat
Harariya K, Rohit Singh T, Kalra A, Padhi S, Ahamed F.   +4 more
europepmc   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

In CASE You Missed It. [PDF]

CASE (Phila)
Sorrell VL.
europepmc   +1 more source