Results 61 to 70 of about 12,459,066 (303)

Numerical evaluating strength reliability of penstocks under hydraulic hammer

open access: yesИнженерно-строительный журнал, 2012
The paper presents a graphical method for estimating the excess pressure in penstocks under partial hydraulic hammer. Based on the proposed method, the maximum design load under hydraulic hammer in a high-pressure penstock of the Zaramagskaya HPP-1 was ...
G.L. Kozinets, L.P. Potekhin
doaj  

A Graphical Method for Great Circle Routes

open access: yesPolish Maritime Research, 2017
A great circle route (GCR) is the shortest route on a spherical earth model. Do we have a visual diagram to handle the shortest route? In this paper, a graphical method (GM) is proposed to solve the GCR problems based on the celestial meridian diagram ...
Hsu Tien-Pen   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Bayesian Covariance Matrix Estimation using a Mixture of Decomposable Graphical Models [PDF]

open access: yes
Estimating a covariance matrix efficiently and discovering its structure are important statistical problems with applications in many fields. This article takes a Bayesian approach to estimate the covariance matrix of Gaussian data.
Christopher K. Carter   +3 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Influence of the type of fastening of multi-layered closing panels on the estimate of the sound transmission loss

open access: yesREM: International Engineering Journal
Industrialized closing systems appear as rational solutions in steel-structured construction. These closing systems, consisting of multi-layered panels, have been applied in projects where it is intended to obtain a high sound transmission loss without ...
Rovadávia Aline de Jesus Ribas   +1 more
doaj   +1 more source

Graphical Entry of FSMDs Revisited:

open access: yes, 2008
This paper discusses issues of graphical modelling of Finite State Machines with Datapath (FSMDs). Tools supporting the graphical entry of state based systems are usable by intuition, but need to be based on an exact definition of semantics of graphical ...
Putting Graphical Models   +1 more
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages [PDF]

open access: yes
The fgui R package is designed for developers of R packages, to help rapidly, and sometimes fully automatically, create a graphical user interface for a command line R package. The interface is built upon the Tcl/Tk graphical interface included in R. The
Thomas J. Hoffmann, Nan M. Laird
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy