Results 141 to 150 of about 1,244,068 (326)

SpiderLearner: An ensemble approach to Gaussian graphical model estimation. [PDF]

open access: yesStat Med, 2023
Shutta KH   +3 more
europepmc   +1 more source

Causal Inference Using Graphical Models with the R Package pcalg

open access: yesJournal of Statistical Software, 2012
The pcalg package for R can be used for the following two purposes: Causal structure learning and estimation of causal effects from observational data.
Markus Kalisch   +4 more
doaj  

Meta graphical lasso: uncovering hidden interactions among latent mechanisms

open access: yesScientific Reports
In complex systems, it’s crucial to uncover latent mechanisms and their context-dependent relationships. This is especially true in medical research, where identifying unknown cancer mechanisms and their impact on phenomena like drug resistance is vital.
Koji Maruhashi   +3 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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