Results 171 to 180 of about 22,175,501 (301)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

AJGM: joint learning of heterogeneous gene networks with adaptive graphical model. [PDF]

Bioinformatics
Yang S, Hu L, Chen P, Zeng X, Mao S.
europepmc   +1 more source

HeteroGGM: an R package for Gaussian graphical model-based heterogeneity analysis. [PDF]

Bioinformatics, 2021
Ren M, Zhang S, Zhang Q, Ma S.
europepmc   +1 more source

Graphical representation of certain moment dualities and application to population models with balancing selection [PDF]

, 2012
Sabine Jansen, Noemi Kurt
openalex   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Bayesian causal graphical model for joint Mendelian randomization analysis of multiple exposures and outcomes. [PDF]

Am J Hum Genet
Zuber V, Cronjé T, Cai N, Gill D, Bottolo L.   +4 more
europepmc   +1 more source

Dietary networks identified by Gaussian graphical model and general and abdominal obesity in adults. [PDF]

Nutr J, 2021
Jayedi A, Janbozorgi N, Djafarian K, Yekaninejad MS, Shab-Bidar S.   +4 more
europepmc   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Penalized estimation of the Gaussian graphical model from data with replicates. [PDF]

Stat Med, 2021
van Wieringen WN, Chen Y.
europepmc   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source