Results 171 to 180 of about 1,309,109 (281)

Penalized estimation of the Gaussian graphical model from data with replicates. [PDF]

Stat Med, 2021
van Wieringen WN, Chen Y.
europepmc   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Bayesian causal graphical model for joint Mendelian randomization analysis of multiple exposures and outcomes. [PDF]

Am J Hum Genet
Zuber V, Cronjé T, Cai N, Gill D, Bottolo L.   +4 more
europepmc   +1 more source

Dietary networks identified by Gaussian graphical model and general and abdominal obesity in adults. [PDF]

Nutr J, 2021
Jayedi A, Janbozorgi N, Djafarian K, Yekaninejad MS, Shab-Bidar S.   +4 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Network Approach to Evaluate the Effect of Diet on Stroke or Myocardial Infarction Using Gaussian Graphical Model. [PDF]

Nutrients
Lailo JM, Shin J, Menichetti G, Lee SA.
europepmc   +1 more source

MODEL FREE ESTIMATION OF GRAPHICAL MODEL USING GENE EXPRESSION DATA. [PDF]

Ann Appl Stat, 2021
Yang J, Liu Y, Liu Y, Sun W.
europepmc   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

A probabilistic graphical model for estimating selection coefficients of nonsynonymous variants from human population sequence data. [PDF]

Nat Commun
Zhao Y, Lan T, Zhong G, Hagen J, Pan H, Chung WK, Shen Y.   +6 more
europepmc   +1 more source

Inter-Subject Analysis: A Partial Gaussian Graphical Model Approach. [PDF]

J Am Stat Assoc, 2021
Ma C, Lu J, Liu H.
europepmc   +1 more source