Results 81 to 90 of about 355,655 (334)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Изобразительное искусство на Первом Уральском культурном форуме

Искусство Евразии, 2019
В июне 2019 года в Екатеринбурге и Свердловской области состоялся Первый Уральский культурный форум. Девиз форума Культура стратегия нации отражает консолидацию творческих центров Уральского федерального округа, создание единого социокультурного ...
Шарко, Галина Александровна
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Graphical decompositions

Discrete Mathematics, 1994
Suppose the vertices of the \(k\)-regular connected graph \(G_ n\) can be partitioned into two sets \(X\) and \(Y\) such that all vertex-degrees in the subgraphs induced by \(X\) and \(Y\) are at least \(\lceil k/2 \rceil\) and \(\lfloor k/2 \rfloor\), respectively.
openaire   +3 more sources

Юбилейные персональные выставки Зураба Церетели за рубежом

Искусство Евразии, 2019
Статья представляет обзор зарубежных выставокЗураба Константиновича Церетели. Зураб Церетели народный художник СССР и Российской Федерации, посол доброй воли ЮНЕСКО, президент Российской академии художеств отметил свой 85-летие в 2019 году.
Федорова, Мария Владиславовна
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Specific Developmental Disorders of School Skills and Phonological Deficit: the Problems of Comorbidity

RUDN Journal of Language Studies, Semiotics and Semantics
The author examines approaches to understanding specific developmental disorders of school skills formulated in Russia, their transformation in the recent decades as well as controversial points concerning the use of the terms ‘dysgraphia ...
Olga A. Velichenkova
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Graphics and Their Grammars

DAIMI Report Series, 1987
<p>Graphics are graphs with attributes at their vertices. Graphic grammars are natural extensions of graph and attribute grammars with rules that are attributed extensions of the ''pushout'' productions of graph grammars. The theory of graphic grammars is presented and various programming implementations will be discussed.
Brian H. Mayoh, Lilia Hess
openaire   +3 more sources