Results 141 to 150 of about 3,309,871 (369)

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

open access: yesFEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

DACIA LOGAN LIVE AXLE OPTIMISATION USING COMPUTER GRAPHICS

open access: yesJournal of Industrial Design and Engineering Graphics, 2017
The paper presents some contributions to the calculus and optimisation of a live axle used at Dacia Logan using computer graphics software for creating the model and afterwards using FEA evaluation to determine the effectiveness of the optimisation. Thus
Andrei Kiraly
doaj   +4 more sources

Realtime multi-plot graphics system [PDF]

open access: yes
The increased complexity of test operations and customer requirements at Langley Research Center's National Transonic Facility (NTF) surpassed the capabilities of the initial realtime graphics system.
Shipkowski, Michael S.
core   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Textbased Modeling [PDF]

open access: yesProceedings of the 4th International Workshop on Software Language Engineering (ateM 2007), Nashville, TN, USA, October 2007 Informatik-Bericht Nr. 4/2007, Johannes-Gutenberg-Universit\"at Mainz, October 2007, 2014
As modeling becomes a crucial activity in software development the question may be asked whether currently used graphical representations are the best option to model systems efficiently. This position paper discusses the advantages of text-based modeling over commonly used graphical representations.
arxiv  

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

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