Results 91 to 100 of about 3,263,133 (311)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Binary Numeration System with Alternating Signed Digits and Its Graph Theoretical Relationship
AlgorithmsThe binary number system is the basic number representation in computing. We can encode natural numbers with finite 0-1 sequences. The representation of natural numbers is based on this system. However, this poses problems and is technically not perfect.
Péter Hajnal
doaj +1 more source
Temporal Graph Traversals Using Reinforcement Learning With Proximal Policy Optimization
IEEE Access, 2020 Graphs in real-world applications are dynamic both in terms of structures and inputs. Information discovery in such networks, which present dense and deeply connected patterns locally and sparsity globally can be time consuming and computationally costly.
Samuel Henrique Silva +2 more
doaj +1 more source
On some intriguing problems in Hamiltonian graph theory -- A survey [PDF]
, 1999 We survey results and open problems in Hamiltonian graph theory centred around three themes: regular graphs, $t$-tough graphs, and claw-free ...
Broersma, H.J.
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Graph Equation for Line Graphs and m-Step Graphs [PDF]
Graphs and Combinatorics, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kim, Seog-Jin +4 more
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
IET Systems BiologySpatially resolved transcriptomics technologies potentially provide the extra spatial position information and tissue image to better infer spatial cell–cell interactions (CCIs) in processes such as tissue homeostasis, development, and disease ...
Han Zhang +9 more
doaj +1 more source
Decision Support for Optimal Repositioning of Containers in a Feeder System
Promet (Zagreb), 2008 The transport of empty containers represents a seriousproblem in the fast growing sphere of maritime container transport.The most widespread type of container transport organizationin maritime transport is the hub and spoke mode, whichenables the ...
Danijela Tuljak-Suban, Elen Twrdy
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source