Results 81 to 90 of about 2,332,619 (281)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
IET Systems BiologySpatially resolved transcriptomics technologies potentially provide the extra spatial position information and tissue image to better infer spatial cell–cell interactions (CCIs) in processes such as tissue homeostasis, development, and disease ...
Han Zhang +9 more
doaj +1 more source
Decision Support for Optimal Repositioning of Containers in a Feeder System
Promet (Zagreb), 2008 The transport of empty containers represents a seriousproblem in the fast growing sphere of maritime container transport.The most widespread type of container transport organizationin maritime transport is the hub and spoke mode, whichenables the ...
Danijela Tuljak-Suban, Elen Twrdy
doaj +1 more source
Random graphs from a weighted minor-closed class [PDF]
, 2012 There has been much recent interest in random graphs sampled uniformly from the n-vertex graphs in a suitable minor-closed class, such as the class of all planar graphs.
McDiarmid, Colin
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Dynamic network participation of functional connectivity hubs assessed by resting-state fMRI
Frontiers in Human Neuroscience, 2014 Network studies of large-scale brain connectivity have demonstrated that highly connected areas, or ‘hubs’, are a key feature of human functional and structural brain organization.
Alexander eSchaefer +10 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
ASA-graphs for efficient data representation and processing
International Journal of Applied Mathematics and Computer Science, 2020 Fast discovering of various relationships in data is an important feature of modern data mining, cognitive, knowledge-based, and explainable AI systems, including deep neural networks.
Horzyk Adrian +2 more
doaj +1 more source