Results 191 to 200 of about 365,547 (358)

Grasp Taxonomy and Grasp Synthesis of Continuum Robots

Continuum robots (CRs) have been the subject of intensive researches in recent years because of the wide range of their potential applications. One main domain of application is CR-based grasp, which needs studying grasp taxonomy and grasp synthesis ...
Ali Mehrkish (18162079)
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Torque and workspace analysis for flexible tendon driven mechanisms

, 2010
Tendon driven mechanisms have been considered in robotic design for several decades. They provide lightweight end effectors with high dynamics. Using remote actuators it is possible to free more space for mechanics or electronics.
Chalon, Maxime, Hirzinger, Gerd, Thomas Wimböck, Wimboeck, Thomas, Gerd Hirzinger, Maxime Chalon   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Independent in the heard: Inclusion and exclusion as social processes. [Elektronisk resurs] : Proceedings from the 9th GRASP conference, Linköping University, May 2014: Independent in the heard: Inclusion and exclusion as social processes. The 9th GRASP conference, Linköping University, May 2014

, 2014
GRASP (Group and Social Psychology) is an interdisciplinary conference, which aims to provide a community around social psychological issues for researchers, practitioners, and graduate students from the Nordic countries within the fields of psychology ...
Lund University., Thornberg, Robert,, Jungert, Tomas,   +2 more
core  

Global Registries and Surveys Programme–Heart Failure (GRASP-HF): Rationale, study design and research implications

Heart failure (HF) is characterized by increasing prevalence, high morbidity and mortality, poor quality of life, and substantial healthcarecosts. Despite advancements in pharmacologic and device-based therapies, translating evidence from randomized ...
Laroche, Cecile, On Behalf Of Grasp-Hf Study National Leaders And Investigators, On Behalf Of Grasp-Hf Study National Leaders And Investigators, Lund, Lars, Savarese, Gianluigi, Demir, Mevlüt, Iung, Bernard, Moura, Brenda Moura, Adamo, Marianna, Krejci, Jan, Volterani, Maurizio, Amir, Offer, Chioncel, Ovidiu, Guillouche, Wendy, Cannata, Antonio Cannata, Doan, Loi Do, Kafafy, Tarek Abdelhameed Nagib Ahmed, Tokmakova, Mariya, Metra, Marco   +17 more
core   +1 more source

Language within our grasp.

Trends in Neurosciences, 1998
G. Rizzolatti, M. Arbib
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source