Results 31 to 40 of about 780,911 (293)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Burial Complex of the 1st Century AD from Kovalyovka Kurgan Gemetery

Нижневолжский археологический вестник, 2016
The present article is devoted to the burial complex of Kurgan No. 8 from Kovalyovka Cemetery located in the south of the Volga-Don interfluve, in the basin of the Aksay Yesaulovsky river. In the center of the burial mound surrounded by a circular ditch,
Aleksandr N. D’jachenko, Mikhail V. Krivosheev   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Understanding The Early Middle Ages: From Life Stories to Grave Goods

, 2023
For the early Middle Ages, there are few primary sources dealing with the lives of everyday people, as the existing ones tend to focus on rich landowners or nobility.
Albrecht, Ciara
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Revisiting Reconstruction of the Early Nomadic Social Structure: Children’s Burials (Southern Urals, 6th – 3rd Centuries BC)

Нижневолжский археологический вестник, 2023
The study concerns the children as one of the social and demographic age groups that formed the early nomads‘ social structure. Burials of two chronological periods were studied: Sauromatian (late 6th – first half of 5th centuries BC) and Early ...
Natalia Berseneva
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Despre cele două morminte din tell-ul de la Dridu

Materiale și Cercetări Arheologice, 2015
Two inhumation graves (M. 1 and M. 2) were found in 1958, buried inside of a so-called tell, situated north of the medieval settlement. The two funerary structures were briefly described and published without any kind of illustration.
Oța, L., Georgescu, M., Baltă, Z.
doaj   +1 more source