Results 21 to 30 of about 247,055 (304)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Does the Intra‐Atomic Deformation Energy of Interacting Quantum Atoms Represent Steric Energy?

ChemistryOpen, 2019
We show that the mutual, through‐space compression of atomic volume experienced by approaching topological atoms causes an exponential increase in the intra‐atomic energy of those atoms, regardless of approach orientation. This insight was obtained using
Benjamin C. B. Symons, Dominic J. Williamson, Campbell M. Brooks, Alex L. Wilson, Prof. Paul L. A. Popelier   +4 more
doaj   +1 more source

Testing alternative models and predictive utility of the Death Anxiety Inventory-Revised: A COVID-19 related longitudinal population based study

Acta Psychologica, 2022
The beginning of the COVID-19 pandemic had a profound effect on all aspects of daily life and triggered a swell of anxiety across the world.
Stephen Waite, Philip Hyland, Kate M. Bennett, Richard P. Bentall, Mark Shevlin   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Investigating the synthesis, reaction pathways, melting points and air sensitivity of Octalithium ceramics, Li8MO6, with M = Sn, Zr, Pb, and Ce

Open Ceramics
Octalithium ceramics (Li8MO6, M = Zr, Pb, Ce, Sn) are highly lithium dense compounds that have been modelled to offer significantly higher tritium breeding ratios (TBRs) compared to the current candidate breeder materials [1].
Pedr Charlesworth, Robert A. House, Peixi Cong, Robert S. Weatherup, David E.J. Armstrong, Chris Grovenor   +5 more
doaj   +1 more source

Microbase2.0: A Generic Framework for Computationally Intensive Bioinformatics Workflows in the Cloud

Journal of Integrative Bioinformatics, 2012
As bioinformatics datasets grow ever larger, and analyses become increasingly complex, there is a need for data handling infrastructures to keep pace with developing technology.
Flanagan Keith, Nakjang Sirintra, Hallinan Jennifer, Harwood Colin, Hirt Robert P., Pocock Matthew R., Wipat Anil   +6 more
doaj   +1 more source

Design Research and Object-Oriented Ontology

Open Philosophy, 2020
In this paper we recount several research projects conducted at ImaginationLancaster (http://imagination.lancs.ac.uk) a Design-led research laboratory, all of which consider Object-Oriented Ontology (OOO).
Lindley Joseph, Akmal Haider Ali, Coulton Paul   +2 more
doaj   +1 more source

SOLPS-ITER predictive simulations of the impact of ion-molecule elastic collisions on strongly detached MAST-U Super-X divertor conditions

Nuclear Fusion, 2023
The role of ion-molecule ( $D^+-D_2$ ) elastic collisions in strongly detached divertor conditions has been studied in the MAST-U Super-X configuration using SOLPS-ITER.
O. Myatra, D. Moulton, B. Dudson, B. Lipschultz, S. Newton, K. Verhaegh, A. Fil   +6 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Factors defining expertise in screening colonoscopy

Endoscopy International Open, 2017
Background and study aims There is very little literature defining characteristics of expert endoscopists. It is hypothesised that previously undetermined human factors may correlate with high performance in screening colonoscopists.
Kinesh Patel, Anna Pinto, Omar Faiz, Matt Rutter, Siwan Thomas-Gibson   +4 more
doaj   +1 more source