Results 51 to 60 of about 1,145,462 (305)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS

Endoscopy International Open, 2016
Background and study aims: Mucosal views can be impaired by residual bubbles and mucus during gastroscopy. This study aimed to determine whether a pre-gastroscopy drink containing simethicone and N-acetylcysteine improves mucosal visualisation.
Peter John Basford, James Brown, Lisa Gadeke, Carole Fogg, Ben Haysom-Newport, Reuben Ogollah, Rupam Bhattacharyya, Gaius Longcroft-Wheaton, Fergus Thursby-Pelham, James R. Neale, Pradeep Bhandari   +10 more
doaj   +1 more source

"The land of my dreams": the gendered utopian dreams and disenchantment of British literary ex-combatants of the Great War [PDF]

, 2011
The last two decades have seen a slow shift in the academic understanding of the impact of the Great War on concepts of gender in interwar Britain. The work of a small group of cultural historians, following in the footsteps of Rosa Maria Bracco, has ...
Cullen, Stephen Michael
core   +1 more source

Influence of an Argon/Silane Atmosphere on the Temperature of a Thermal Plasma

Advanced Engineering Materials, EarlyView.
The influence of a silane‐doped argon atmosphere on the chemical composition and temperature of a thermal nontransferring argon plasma is investigated using optical emission spectroscopy. As a result of the high amount of free electrons resulting from the stepwise ionization and dissociation of the silane molecule, even a silane addition of 0.01 vol ...
Lena Kreie, David Kramer, Thomas Scheithauer, Hans Jürgen Maier, Thomas Hassel   +4 more
wiley   +1 more source

Ceftolozane-tazobactam in combination with fosfomycin for treatment of MDR/XDR P. aeruginosa infective endocarditis

Clinical Infection in Practice, 2019
Background: Infective endocarditis (IE) due to multi-drug (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa is rare. MDR P. aeruginosa infections are increasingly reported worldwide, and the choice of effective antimicrobials is limited ...
A. Prescott, S. Kennedy, P. Howard, T. Collyns, M.H. Gilleece, F. Pirone, M.W. Baig, C. Donnellan, J.A.T. Sandoe   +8 more
doaj   +1 more source

Deterministic Detection of Single Ion Implantation

Advanced Engineering Materials, EarlyView.
Focused ion beam implantation with high detection efficiencies will enable the rapid and scalable fabrication of advanced spin‐based technologies such as qubits. This work presents the detection efficiencies of a wide range of ions implanted into solid‐state hosts, with efficiencies of >90% recorded for ion species and substrate combinations of ...
Mason Adshead, Lok Kan Wan, Maddison Coke, Janet Jacobs, Nicholas F. L. Collins, Mark C. Rosamond, Richard J. Curry   +6 more
wiley   +1 more source

Achievement of ion temperatures in excess of 100 million degrees Kelvin in the compact high-field spherical tokamak ST40

Nuclear Fusion, 2023
Ion temperatures of over 100 million degrees Kelvin (8.6 keV) have been produced in the ST40 compact high-field spherical tokamak (ST). Ion temperatures in excess of 5 keV have not previously been reached in any ST and have only been obtained in much ...
S.A.M. McNamara, O. Asunta, J. Bland, P.F. Buxton, C. Colgan, A. Dnestrovskii, M. Gemmell, M. Gryaznevich, D. Hoffman, F. Janky, J.B. Lister, H.F. Lowe, R.S. Mirfayzi, G. Naylor, V. Nemytov, J. Njau, T. Pyragius, A. Rengle, M. Romanelli, C. Romero, M. Sertoli, V. Shevchenko, J. Sinha, A. Sladkomedova, S. Sridhar, Y. Takase, P. Thomas, J. Varje, B. Vincent, H.V. Willett, J. Wood, D. Zakhar, D.J. Battaglia, S.M. Kaye, L.F. Delgado-Aparicio, R. Maingi, D. Mueller, M. Podesta, E. Delabie, B. Lomanowski, O. Marchuk, the ST40 Team   +41 more
doaj   +1 more source