Results 41 to 50 of about 27,887 (259)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Optimization of PWSN transmission performance on coal mining face

Gong-kuang zidonghua, 2020
In view of problems of long end-to-end time and high packet loss rate of positioning wireless sensor network (PWSN) on coal mining face, a guaranteed greedy scheduling (GGS) algorithm was proposed to optimize network transmission performance.
FANG Zuhao, ZHAO Xiaohu, WANG Haibo, WANG Jingjing   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Energy-Efficient Chain Formation Algorithm for Data Gathering in Wireless Sensor Networks

International Journal of Distributed Sensor Networks, 2012
In wireless sensor networks, since sensor nodes are distributed in inaccessible regions for data gathering, they need to be operated during an assigned time without battery recharging and relocation.
Se-Jung Lim, Myong-Soon Park
doaj   +1 more source

The Feature Compression Algorithms for Identifying Cytokines Based on CNT Features

IEEE Access, 2020
As the signaling proteins, cytokines regulate a wide range of biological functions. It is important to distinguish the cytokines from other kinds of proteins.
Guilin Li, Xing Gao
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Distributed Flow Shop Scheduling with Sequence-Dependent Setup Times Using an Improved Iterated Greedy Algorithm

Complex System Modeling and Simulation, 2021
To meet the multi-cooperation production demand of enterprises, the distributed permutation flow shop scheduling problem (DPFSP) has become the frontier research in the field of manufacturing systems. In this paper, we investigate the DPFSP by minimizing
Xue Han, Yuyan Han, Qingda Chen, Junqing Li, Hongyan Sang, Yiping Liu, Quanke Pan, Yusuke Nojima   +7 more
doaj   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

An Improved Q-Learning Algorithm and Its Application in Path Planning

Taiyuan Ligong Daxue xuebao, 2021
Traditional Q-Learning algorithm has the problems of too many random searches and slow convergence speed. Therefore, in this paper an improved ε-Q-Learning algorithm based on traditional Q-Learning algorithm was propased and applied to path planning. The
Guojun MAO, Shimin GU
doaj   +1 more source