Results 121 to 130 of about 48,754 (287)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

GREEN'S FUNCTION FOR RIGIDLY FIXED PLATE

Structural Mechanics of Engineering Constructions and Buildings, 2010
A problem of finding of displacements of a rigidly fixed plate loaded by concentrated force is examined. As an example, there was taken a triangle plate for which the function of Green was built with the help of the system «Mathematica».
Alexandr Alexandrovitch Timofeyev
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Iterative Integro-Differential Techniques Based on Green’s Function for Two-Point Boundary-Value Problems of Ordinary Differential Equations

Axioms
Several iterative integro-differential formulations for two-point, second- and third-order, nonlinear, boundary-value problems of ordinary differential equations based on Green’s functions and the method of variation of parameters are presented.
Juan I. Ramos
doaj   +1 more source

Renormalized Singles Green's Function in the T-Matrix Approximation for Accurate Quasiparticle Energy Calculation. [PDF]

J Phys Chem Lett, 2021
Li J, Chen Z, Yang W.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A causality-based divide-and-conquer algorithm for nonequilibrium Green’s function calculations with quantics tensor trains

SciPost Physics
We propose a causality-based divide-and-conquer algorithm for nonequilibrium Green's function calculations with quantics tensor trains. This algorithm enables stable and efficient extensions of the simulated time domain by exploiting the causality of ...
Ken Inayoshi, Maksymilian Środa, Anna Kauch, Philipp Werner, Hiroshi Shinaoka
doaj   +1 more source

Multiscale Green's function for silicene and its application to calculation of the strain field due to a vacancy. [PDF]

MRS Adv, 2021
Tewary VK, Garboczi EJ.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Green's Function for Discrete Second-Order Problems with Nonlocal Boundary Conditions

Boundary Value Problems, 2011
We investigate a second-order discrete problem with two additional conditions which are described by a pair of linearly independent linear functionals.
Roman Svetlana, Štikonas Artūras   +1 more
doaj