Results 131 to 140 of about 55,033 (326)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source
Green's Function with Generalized Boundary Conditions [PDF]
, 1967 Toshitake Takahashi
openalex +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
A singular third-order 3-point boundary-value problem with nonpositive Green's function
Electronic Journal of Differential Equations, 2007 We find a Green's function for the singular third-order three-point BVP $$ u'''(t)=-a(t)f(t,u(t)),quad u(0)=u'(1)= u''(eta )=0 $$ where $0leq eta
Anastasia N. Veloni, Alex P. Palamides
doaj
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
A Green's Function Wind Turbine Induction Model That Incorporates Complex Inflow Conditions
Wind EnergyIn this work, we develop a new analytical turbine induction model that can incorporate complex inflow conditions including cases where the wind velocity and temperature profiles can vary as functions of height.
Lawrence Cheung +6 more
doaj +1 more source
Symbolic algorithm to solve initial value problems for partial differential equations
Bulletin of Computational Applied Mathematics, 2020 In this paper, we present a new symbolic algorithm for finding the Green's function of a given initial value problem for linear partial differential equations of second order with constant coefficients.
Srinivasarao Thota, Shiv Datt Kumar
doaj
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Even order self adjoint time scale problems
Electronic Journal of Differential Equations, 2005 Even order self adjoint differential time scale expressions are introduced, together with associated self adjoint boundary conditions; the result is established by induction. Several fourth-order nabla-delta delta-nabla examples are given for select self
Douglas R. Anderson, Joan Hoffacker
doaj