Results 31 to 40 of about 7,672 (218)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Linear ODE with nonlocal boundary conditions and Green’s functions for such problems

open access: yesLietuvos Matematikos Rinkinys, 2019
In this article we investigate a formula for the Green’s function for the n-order linear differential equation with n additional conditions. We use this formula for calculating the Green’s function for problems with nonlocal boundary conditions.
Svetlana Roman, Artūras Štikonas
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

RAPID CALCULATION OF THE THERMAL IMPULSE TRANSIENT STRESS OF THE PRESSURIZER SPRAY NOZZLE BASED ON DOUBLE TEMPERATURE BOUNDARY GREEN’S FUNCTION

open access: yesJixie qiangdu, 2020
The thermal transient load of the primary loop nuclear pipeline will cause fatigue damage at sensitive locations.And cumulative fatigue damage factors of these sensitive locations need to be monitored during the life extension of the nuclear power plant ...
WANG WeiWei   +4 more
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Some thermal properties of ideal gas

open access: yesEuropean Physical Journal C: Particles and Fields
In this article, we investigate the thermal properties of non-relativistic many-body systems at finite temperatures and chemical potential. We compute the one-point function of various operators constructed out of the basic fields in ideal bosonic and ...
Rajesh Kumar Gupta, Meenu
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Green’s Function for Non-Homogeneous Magneto-Electro-Elastic Half-Plane

open access: yesEngineering Proceedings
An exponentially graded magneto-electro-elastic (MEE) half-plane subjected to anti-plane mechanical and in-plane electric and magnetic time-harmonic external load is considered.
Yonko Stoynov
doaj   +1 more source

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