Results 41 to 50 of about 7,672 (218)
Қарағанды университетінің хабаршысы. Математика сериясы, 2018 In this paper the question on unconditional basicity of the system of eigenfunctions of the involutive perturbed Sturm-Liouville operator is investigated.
A.A. Sarsenbi
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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Journal of Marine Science and EngineeringThe frequency-domain free-surface Green’s function method is widely used in solving ship hydrodynamic problems, with its core challenge lying in the computation of the Green’s function and its partial derivatives.
Minmin Zheng +5 more
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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Green’s Function Estimates for Time-Fractional Evolution Equations
Fractal and Fractional, 2019 We look at estimates for the Green’s function of time-fractional evolution equations of the form D 0 + ∗ ν u = L u , where D 0 + ∗ ν is a Caputo-type time-fractional derivative, depending on a Lévy ...
Ifan Johnston, Vassili Kolokoltsov
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Green’s function approach to the non-relativistic radial wavefunction using Hulthen potential
Physics Letters BAn approximate analytical solution to the radial Schrodinger equation for the generalized Hulthen potential is derived using a modified centrifugal term approximation method.
Adithya Anil +4 more
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