Results 61 to 70 of about 307,504 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sustainable farming with native rocks: the transition without revolution. [PDF]

, 2006
The development process which humanity passed through favored a series of conquests, reflected in the better quality of life and longevity, however, it also provoked upsets and severe transformation in the environment and in the human food security. Such
ALTIERI MA, DISSANAYAKE DB, FONSECA R, FYFE WS, LEONARDOS OH, LEONARDOS OH, LEONARDOS OH, MELFI AJ, Othon H. Leonardos, SHIKI S, SMEDLEY PL, SMITH B, Suzi H. Theodoro, THEODORO SCH, VAN STRAATEN P, William S. Fyfe   +15 more
core   +4 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Incorporating Recyclates Derived from Household Waste into Flexible Food Packaging Applications: An Environmental Sustainability Assessment

Recycling
Integrating recyclates into food packaging is key towards circularity while meeting functionality and safety requirements; however, associated environmental impacts remain underexplored.
Trang T. Nhu, Anna-Sophie Haslinger, Sophie Huysveld, Jo Dewulf   +3 more
doaj   +1 more source

Sustainable synthesis of amino acids by catalytic fixation of molecular dinitrogen and carbon dioxide [PDF]

, 2018
The industrial process of nitrogen fixation is complex and results in a huge economic and environmental impact. It requires a catalyst and high temperature and pressure to induce the rupture of the strong N–N bond and subsequent hydrogenation.
Alemán Llansó, Carlos, Puiggalí Bellalta, Jordi, Rivas Cañas, Manuel, Turón Dols, Pau, Valle Mendoza, Luis Javier del   +4 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

Frontiers in Chemistry, 2022
The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry drug ...
Ludovica Marotta, Sara Rossi, Roberta Ibba, Simone Brogi, Vincenzo Calderone, Stefania Butini, Giuseppe Campiani, Sandra Gemma   +7 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Integrating social and environmental justice into the chemistry classroom: a chemist’s toolbox

Green Chemistry Letters and Reviews, 2019
Although the chemical enterprise has provided numerous contributions to humanity, unintended consequences contribute to a disproportionate exposure of hazardous chemicals to certain populations based on race and socioeconomic status. Integrating concepts
Grace A. Lasker, Edward J. Brush
doaj   +1 more source

Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones [PDF]

, 2007
The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route.
Clarke, Paul A., Martin, William H. C., Santos, Soraia   +2 more
core   +1 more source