Results 111 to 120 of about 2,546,109 (292)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Axial Cyclic Testing of Concrete-Filled Steel Tube Columns in Diagrid Structures

open access: yesAdvances in Civil Engineering, 2019
Inclined concrete-filled steel tube (CFST) columns in a diagrid structure system can efficiently carry large vertical loads and horizontal forces. This paper presents an experimental study of the stress characteristics of engineered inclined CFST columns
Qingxuan Shi, Wenzhe Cai, Bin Wang
doaj   +1 more source

Greening Historic DC: Challenges and Opportunities to Incorporate Historic Preservation into the District\u27s Drive for Sustainable Development [PDF]

open access: yes, 2009
This paper focuses primarily on the District of Columbia, a city with a robust past and a bold agenda for a sustainable future. However, it may not be obvious why historic preservation - a movement typically concerned with aesthetics - can play an ...
Stein, Andrew
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Effect of different buried depth on the disintegration characteristic of red-bed soft rock and the evolution model of disintegration breakage under cyclic drying-wetting

open access: yesScientific Reports
The disintegration of red-bed soft rock exhibits a strong correlation with various geological disasters. However, the investigation into the evolutionary mechanisms underlying disintegration breakage has not yet received extensive exploration.
Jun Zhang   +7 more
doaj   +1 more source

The Application of Green Design in the Interior Room in Terms of Material Selection [PDF]

open access: yes, 2019
Design with the Green Design approach is now starting to get more attention in interior planning in big cities in Indonesia. Human awareness about the environment and healthy living space is a driving factor.
Sudarisman, I. (Irwan )
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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