Results 101 to 110 of about 465,577 (300)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A schistosome [beta] subunit remodels inactivation of a calcium channel _via_ an N-terminal polyacidic motif

open access: yes, 2010
The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg   +1 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Dual-Channel Supply Chain Coordination Considering Green and Service Inputs

open access: yes
The rise of the green economy and the dual-channel model has led to consumer preferences for a model that is both green and service-based. At the same time, customer service expectations have led to greater uncertainties in corporate decision-making ...
Yefeng Guan, Wei Wang, Chao Wan
core   +1 more source

Interactions between coarse sediment transfer, channel change, river engineering and flood risk in an upland gravel-bed river [PDF]

open access: yes, 2008
Coarse sediment transfer in upland gravel-bed river systems is often neglected in the design and operation of river management schemes. Yet, it is increasingly attributed to problems within upland environments including bank erosion and enhanced flood ...
Waterhouse, Emma Kate
core  

Green Wi-Fi Management: Implementation on Partially Overlapped Channels

open access: yesIEEE Transactions on Green Communications and Networking, 2018
The channel assignment in the non-overlapped channel space may result in low spatial utilization and non-uniform Wi-Fi performance, which makes it difficult to cater to the rapid increase in Wi-Fi devices as well as wireless traffic demand. In this paper, we propose a Green Wi-Fi management framework for an enterprise environment in order to densely ...
Yaodong Zhang   +5 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Two-Channel Green Supply Chain Pricing Decisions Considering Advertising in Centralized and Decentralized Modes [PDF]

open access: yesMuṭāli̒āt-i Mudīriyyat-i Ṣan̒atī
One of the most critical decisions in the supply chain is pricing, playing a vital role in the profitability of the entire supply chain. In this research, a two-tier green supply chain is considered, comprising a producer and a retailer, where two types ...
Parisa Hosseini, Mehdi Seifbarghy
doaj   +1 more source

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