Results 81 to 90 of about 465,577 (300)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Enhanced “Green Nudging”: Tapping the channels of cultural transmission

PLOS One
This paper shows how to increase the effectiveness of “green nudging” as a policy measure to induce sustainable preferences. Evidence indicates that the behavioral impact of “green nudges” is subject to decay. To address this problem, we propose “enhanced green nudges”, which incorporate learning biases as features of humans’ capacity for culture ...
Christian Cordes, Joshua Henkel
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Green design strategies for sustainable supply chain considering channel leadership

We have observed from practice that to create new economic and environmental values, both the upstream and downstream firms in sustainable supply chain are motivated to invest in green design.
Fengmin Yao, Likun Liu, Yingluo Yan, Jiayi Sun   +3 more
core   +1 more source

Channel Selection Strategies of Chinese E-Commerce Supply Chains Under Green Governmental Subsidies

Systems
In the era of the green digital economy, network platforms as a new form of economic format have gained significant attention from e-commerce companies.
Lingyu Gao, Xiaoli Wang, Xu Xin
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Blind Single Channel Deconvolution using Nonstationary Signal Processing

, 2003
Blind deconvolution is fundamental in signal processing applications and, in particular, the single channel case remains a challenging and formidable problem. This paper considers single channel blind deconvolution in the case where the degraded observed
Rayner, Peter J. W., Hopgood, James; id_orcid   +1 more
core   +1 more source

多元化教学模式在大学附属教学医院卒中绿色通道培训中的应用 Application of Diversified Teaching Model in Stroke Green Channel Training at a Medical University-Affiliated Teaching Hospital

Zhongguo cuzhong zazhi
目的 本文以大学附属教学医院的卒中急救绿色通道培训医师为主要研究对象，旨在提高新进医疗岗位医师的学习效率，改善临床工作的多种质控指标。 方法 设计多元化教学方法，包括临床案例式协作教学法、基于问题教学法、翻转课堂、一带一学习、情景模拟及临床疗效反馈等，以一家教学医院区域性高级卒中中心的绿色通道患者和医师为调查对象，收集多环节时间点的质控指标以及教学互评反馈来评价教学效果。 结果 纳入2021年6月—2023年7月急诊卒中绿色通道诊疗环节中符合条件的患者194例 ...
王也，魏宸铭，李秀丽，武剑(WANG Ye, WEI Chenming, LI Xiuli, WU Jian )
doaj  

Red (660 nm) or near-infrared (810 nm) photobiomodulation stimulates, while blue (415 nm), green (540 nm) light inhibits proliferation in human adipose-derived stem cells

Scientific Reports, 2017
We previously showed that blue (415 nm) and green (540 nm) wavelengths were more effective in stimulating osteoblast differentiation of human adipose-derived stem cells (hASC), compared to red (660 nm) and near-infrared (NIR, 810 nm).
Yuguang Wang, Ying-Ying Huang, Yong Wang, Peijun Lyu, Michael R. Hamblin   +4 more
doaj   +1 more source