Results 91 to 100 of about 3,352,793 (292)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Ron Green Sr. and Eleanor Green interview

open access: yes, 2002
Bothell, Washington, United StatesThis interview of Ron and Eleanor Green took place at the Hannan House, Bothell, Washington, in July 2002.
Green, Ron Sr.; Green, Eleanor
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Strategic Interactions in Omni-Channel Retailing: Analyzing Manufacturer’s Green Contract Design and Mode Selection

open access: yesJournal of Theoretical and Applied Electronic Commerce Research
Omni-channel retailers arise to address the deficiencies in consumers’ online shopping experiences; the resulting competition between such retailers and traditional online platforms presents substantial challenges for green product manufacturers. A three-
Zhibing Liu, Chi Zhou
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Ohio consumer's guide to buying a solar electric system

open access: yes, 2004
Title from cover of PDF document (viewed Mar. 17, 2006).; "... Produced by Green Energy Ohio with the support of the Ohio Department of Development Office of Energy Efficiency"--P.
Green Energy Ohio.
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Multi-user indoor optical wireless communication system channel control using a genetic algorithm [PDF]

open access: yes, 2011
A genetic algorithm controlled multispot transmitter is demonstrated that is capable of optimising the received power distribution for randomly aligned single element receivers in multiple fully diffuse optical wireless communications systems with ...
M.S. Leeson   +7 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Benazir Hussain of West Australian Ballet, May 2004 [picture] /

open access: yes, 2004
Part of collection: Jon Green collection of photographs of Australian dancers and choreographers.; Title supplied by photographer.; Image from Jon Green's private collection 'avec attitude'.; Acquired in digital format; access copy available online ...
Green, Jon.
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