Results 161 to 170 of about 1,541,834 (325)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Nanocatalysis for Environmental Protection, Energy, and Green Chemistry. [PDF]

open access: yesNanomaterials (Basel), 2023
Panagiotopoulou P, Yentekakis IV.
europepmc   +1 more source

Chemists and the School of nature

open access: yes, 2002
International audienceBiomimetism is an umbrella covering a variety of research fields ranging from the chemistry of natural products to nanocomposites, via biomaterials and supramolecular chemistry. . It is an informal movement and the concept itself is
Arribart, Hervé   +3 more
core   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Engaging students for meaningful chemistry learning through microcomputer-based laboratory (MBL) inquiry : Promoure en els estudiants l’aprenentatge significatiu de la química mitjançat treballs pràctics indagatius amb l’ús d’equips de captació de dades amb sensors (MBL) [PDF]

open access: yes, 2011
The Microcomputer-based Laboratory (MBL) can be an example of a student-centered learning environment that provides new opportunities to engage secondary-level chemistry students in meaningful learning and higher-order thinking through inquiry.
Aksela, Maija Katariina
core  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Chemistry Goes Green [PDF]

open access: bronze, 2002
Julia Fahrenkamp-Uppenbrink
openalex   +1 more source

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