Results 51 to 60 of about 534,009 (248)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Microwave-Assisted Green Production of Furfural from D-xylose of Sugarcane Bagasse

BioResources, 2015
D-xylose is a component of sugarcane bagasse that can be used as a renewable resource for the production of a variety of chemicals. By means of catalytic reactions in an aqueous medium, it was determined that D-xylose can efficiently be converted into ...
Sílvio Vaz Jr., Paulo Marcos Donate
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Optimizing the implementation of safe and sustainable by design to better enable sustainable innovation

iScience
Summary: The concept of safe and sustainable by design (SSbD) combines considerations of human safety, environmental safety, and sustainability. The SSbD framework developed by the European Commission’s (EC) Joint Research Centre (JRC) and the Safe(r ...
Ramya Rajagopal, Florence Bohnes, Predrag Kukic, Giles Rigarlsford, Evita Vandenbossche-Goddard, Bruno Campos, Claire Davies, Ian Malcomber, Gavin Maxwell, Sarah Sim   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Awareness of chemistry teachers of gender influence on perceptions and attitudes to green chemistry in Kwara State, Nigeria

The Dyke
Guided by the principles of environmental sustainability, and drawing on extant literature that highlight the limited integration of green chemistry in secondary science education, this study examined the influence of gender on chemistry teachers ...
David Adeyemi Aladesuyi, Florence Abidoye, Adekunle Omotayo Abidoye   +2 more
doaj   +1 more source

PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK BERDASARKAN KERAGAMAN JENIS TANAMAN DI GREEN CHEMISTRY DAN KEBUN BIOLOGI UNIVERSITAS BENGKULU

Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi, 2019
Keanekaragaman hayati Indonesia dapat dijadikan sebagai sumber belajar dan dikembangkan menjadi bahan ajar bagi peserta didik. Melalui penelitian ini, akan dikembangkan bahan ajar berupa Lembar Kegiatan Peserta Didik (LKPD) berdasarkan sumber belajar ...
Orin Uniati, Dewi Jumiarni, Ariefa Primair Yani   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source