Results 71 to 80 of about 4,476,226 (254)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Turning mustard gas chemistry into green chemistry: a new tool for pharmaceutical synthesis [PDF]
, 2021 N,N -dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts and especiallypharmaceuticals such as Tamoxifen, Raloxifene, Amiodarone, Phenyltoloxamine, Trifenagrel and Trimethobenzamide.Common synthetic procedures for ...
Giacomo Trapasso +2 more
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Editorial for the "Green Chemistry" Section in the Journal Molecules:Focus on Solvents [PDF]
, 2020 It is a pleasure to write this editorial highlighting some of the recent papers discussing solvents in the Green Chemistry section of Molecules [...]
Sherwood, James, James Sherwood
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Conference report: Lake Constance turns green
, 2009 Adamova, G.; Ferguson, J.; Ng, S.; Puga Vaca, A.; Rodriguez, H.; Rountree, S.; Seddon, K.... (2009). Conference report: Lake Constance turns green. Green Chemistry. 11(5):604-608. doi:10.1039/b822925mS604608115Horváth, I.
Ng, S. +7 more
core +1 more source
Green Chemistry: Progress and Barriers [PDF]
, 2016 Green chemistry can advance both the health of the environment and the primary objectives of the chemical enterprise: to understand the behavior of chemical substances and to use that knowledge to make useful substances.
Green, Sarah A.
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dos primeiros aos segundos doze princípios da Química Verde
Química Nova, 2012 The second 12 principles of Green Chemistry (Winterton, 2001) are presented and discussed to show how they press academic chemists to focus the invention of synthetic pathways more directly on industrial process development, allowing a quicker progress ...
Adélio A. S. C. Machado
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source