Results 81 to 90 of about 5,045,211 (295)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
iScienceSummary: The concept of safe and sustainable by design (SSbD) combines considerations of human safety, environmental safety, and sustainability. The SSbD framework developed by the European Commission’s (EC) Joint Research Centre (JRC) and the Safe(r ...
Ramya Rajagopal +9 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Green Map Flushing Meadow Queens NY
, 2005 A map of Flushing Meadows Corona Park in Queens, NY, site of two world fairs (1939 and 1964) currently home to a number of recreation facilities and green space.
Green Map System (Firm)
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The DykeGuided by the principles of environmental sustainability, and drawing on extant literature that highlight the limited integration of green chemistry in secondary science education, this study examined the influence of gender on chemistry teachers ...
David Adeyemi Aladesuyi +2 more
doaj +1 more source
Turning mustard gas chemistry into green chemistry: a new tool for pharmaceutical synthesis [PDF]
, 2021 N,N -dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts and especiallypharmaceuticals such as Tamoxifen, Raloxifene, Amiodarone, Phenyltoloxamine, Trifenagrel and Trimethobenzamide.Common synthetic procedures for ...
Giacomo Trapasso +2 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi, 2019 Keanekaragaman hayati Indonesia dapat dijadikan sebagai sumber belajar dan dikembangkan menjadi bahan ajar bagi peserta didik. Melalui penelitian ini, akan dikembangkan bahan ajar berupa Lembar Kegiatan Peserta Didik (LKPD) berdasarkan sumber belajar ...
Orin Uniati +2 more
doaj +1 more source
Future green chemistry and sustainability needs in polymeric coatings
, 2022 S.4919-4926Polymeric coatings play a critical role in a diverse range of products used in virtually every facet of our society, including infrastructure, architecture, automotives and transportation, food packaging, electronics and health care.
Robert, Tobias +6 more
core +1 more source