Results 41 to 50 of about 264,984 (260)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons

Nature Communications
Scaffold hopping is a key strategy in drug discovery. While one-to-one scaffold hopping strategies are thriving and evolving, one-to-multiple strategies remain challenging to design.
Shun Li, Yonglin Shi, Juan Tang, Meixin Yan, Shunyao Huang, Tingying Dou, Shenxiang Wang, Xinchao Jin, Zhishan Su, Weidong Jiang, Jiaqi Xu, Xueli Zheng, Ruixiang Li, Hua Chen, Weichao Xue, Haiyan Fu   +15 more
doaj   +1 more source

Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

Nature Communications, 2019
Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu, Xiaoming Feng   +4 more
doaj   +1 more source

Arylcarboxylation of unactivated alkenes with CO2 via visible-light photoredox catalysis

Nature Communications, 2023
Photocatalytic carboxylation of alkenes with CO2 is a promising and sustainable strategy to synthesize high value-added carboxylic acids. However, it is challenging and rarely investigated for unactivated alkenes due to their low reactivities. Herein, we
Wei Zhang, Zhen Chen, Yuan-Xu Jiang, Li-Li Liao, Wei Wang, Jian-Heng Ye, Da-Gang Yu   +6 more
doaj   +1 more source

High School Sustainable and Green Chemistry: Historical–Epistemological and Pedagogical Considerations

Sustainable Chemistry, 2023
In this paper, a distinction is first made between environmental, sustainable, and green chemistry; the last two are then examined in relation to the more general problem of environmental education.
Teresa Celestino
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Transition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis

Nature Communications, 2019
Phosphonyl and carboxyl groups are valuable functional groups, however their simultaneous incorporation via catalytic difunctionalization of alkenes has not been realized yet.
Qiang Fu, Zhi-Yu Bo, Jian-Heng Ye, Tao Ju, He Huang, Li-Li Liao, Da-Gang Yu   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Applicability of green chemistry principles for optimum environmental conservation and sustainability in sub-Saharan Africa

Green Chemistry Letters and Reviews
The African region south of the Sahara Desert is important in the global socio-economic landscape owing to its natural resources, agricultural potential, and emerging industrialization.
Harieth Hellar-Kihampa
doaj   +1 more source

One-pot synthesis of four-coordinate boron(III) complexes by the ligand-promoted organic group migration between boronic acids

Scientific Reports, 2017
Multidisciplinary applications of four-coordinate boron(III) complexes make them very attractive and challenging research field in chemistry, biology and material sciences.
Venkata S. Sadu, Hye-Rin Bin, Do-Min Lee, Kee-In Lee   +3 more
doaj   +1 more source