Results 51 to 60 of about 11,788,821 (250)

Skeletal editing of 4-arylpyrimidines into diverse nitrogen heteroaromatics via four-atom synthons

Nature Communications
Scaffold hopping is a key strategy in drug discovery. While one-to-one scaffold hopping strategies are thriving and evolving, one-to-multiple strategies remain challenging to design.
Shun Li, Yonglin Shi, Juan Tang, Meixin Yan, Shunyao Huang, Tingying Dou, Shenxiang Wang, Xinchao Jin, Zhishan Su, Weidong Jiang, Jiaqi Xu, Xueli Zheng, Ruixiang Li, Hua Chen, Weichao Xue, Haiyan Fu   +15 more
doaj   +1 more source

Arylcarboxylation of unactivated alkenes with CO2 via visible-light photoredox catalysis

Nature Communications, 2023
Photocatalytic carboxylation of alkenes with CO2 is a promising and sustainable strategy to synthesize high value-added carboxylic acids. However, it is challenging and rarely investigated for unactivated alkenes due to their low reactivities. Herein, we
Wei Zhang, Zhen Chen, Yuan-Xu Jiang, Li-Li Liao, Wei Wang, Jian-Heng Ye, Da-Gang Yu   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Transition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis

Nature Communications, 2019
Phosphonyl and carboxyl groups are valuable functional groups, however their simultaneous incorporation via catalytic difunctionalization of alkenes has not been realized yet.
Qiang Fu, Zhi-Yu Bo, Jian-Heng Ye, Tao Ju, He Huang, Li-Li Liao, Da-Gang Yu   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A unified strategy toward total syntheses of lindenane sesquiterpenoid [4 + 2] dimers

Nature Communications, 2019
Of the 3 classes of dimeric lindenane sesquiterpenoids, only type I And II have been targeted in total synthesis. Here, the authors report a unified strategy to synthetically access the 3 classes of lindenane sesquiterpenoids dimers by developing a [4 ...
Biao Du, Zhengsong Huang, Xiao Wang, Ting Chen, Guo Shen, Shaomin Fu, Bo Liu   +6 more
doaj   +1 more source

Simple green organic chemistry experiments with the kitchen microwave for high school chemistry classrooms

Chemistry Teacher International, 2022
Microwave systems have been used in organic chemistry since the late 1990s for applications including Microwave-Assisted Organic Synthesis (MAOS). The main advantages of microwave-assisted procedures compared to traditional synthesis methods are the 100-
Linkwitz Michael, Zidny Robby, Nida Safwatun, Seeger Lea, Belova Nadja, Eilks Ingo   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Applicability of green chemistry principles for optimum environmental conservation and sustainability in sub-Saharan Africa

Green Chemistry Letters and Reviews
The African region south of the Sahara Desert is important in the global socio-economic landscape owing to its natural resources, agricultural potential, and emerging industrialization.
Harieth Hellar-Kihampa
doaj   +1 more source

One-pot synthesis of four-coordinate boron(III) complexes by the ligand-promoted organic group migration between boronic acids

Scientific Reports, 2017
Multidisciplinary applications of four-coordinate boron(III) complexes make them very attractive and challenging research field in chemistry, biology and material sciences.
Venkata S. Sadu, Hye-Rin Bin, Do-Min Lee, Kee-In Lee   +3 more
doaj   +1 more source