Results 71 to 80 of about 272,000 (300)

Enantioselective homologation of helical architectures from fluorenones to phenanthrenones with enhanced circular dichroism

Nature Communications
The development of efficient synthetic methods to access optically pure helical chiral molecules is a central challenge in organic chemistry due to their unique photophysical properties and potential applications in chiral photonic devices.
Shiyang Li, Shi Yan, Zhenzhong Liu, Yang Zhang, Yuqiao Zhou, Xiaoming Feng, Liang-Wen Feng, Xiaohua Liu   +7 more
doaj   +1 more source

Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives

Nature Communications, 2018
The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild ...
Pei Liu, Changpeng Chen, Xuefeng Cong, Jinghua Tang, Xiaoming Zeng   +4 more
doaj   +1 more source

Green Extraction of Natural Products: Concept and Principles [PDF]

, 2012
The design of green and sustainable extraction methods of natural products is currently a hot research topic in the multidisciplinary area of applied chemistry, biology and technology.
Cravotto, Giancarlo, Farid Chemat, Giancarlo Cravotto, Maryline Abert Vian, Abert Vian, Maryline, Chemat, Farid, Vian, Maryline   +6 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Metal–carbene-guided twofold cross-coupling of ethers with chromium catalysis

Nature Communications
Coupling by metal–carbene transfer enables the formation of several different bonds at the carbenoid site, enabling prochiral Csp 3 centers that are fundamental three-dimensional substructures for medicines to be forged with increased efficiency. However,
Fei Fan, Yong Peng, Xiaoyu Zhang, Sha Wang, Zheng Luo, Meiming Luo, Xiaoming Zeng   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Synthesis and redox catalysis of Carbodiphosphorane ligated stannylene

Nature Communications
Heavier group 14 carbene analogues, exhibiting transition-metal-like behavior, display remarkable capability for small molecule activation and coordination chemistry. However, their application in redox catalysis remains elusive. In this paper, we report
Zhuchunguang Liu, Zhijun Wang, Huan Mu, Yihan Zhou, Jiliang Zhou, Zhaowen Dong   +5 more
doaj   +1 more source

CALB Immobilized onto Magnetic Nanoparticles for Efficient Kinetic Resolution of Racemic Secondary Alcohols: Long-Term Stability and Reusability

Molecules, 2019
In this study, an immobilization strategy for magnetic cross-linking enzyme aggregates of lipase B from Candida antarctica (CALB) was developed and investigated. Magnetic particles were prepared by conventional co-precipitation.
Xiu Xing, Jun-Qi Jia, Jing-Fan Zhang, Zi-Wen Zhou, Jun Li, Na Wang, Xiao-Qi Yu   +6 more
doaj   +1 more source

Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System. [PDF]

Molecules, 2023
Al-Zaydi KM, Saleh TS, Alqahtani NF, Bagazi MS.   +3 more
europepmc   +1 more source